Novel phenothiazine analogous: Synthesis and a new perceptivity into their antioxidant potential

Nagaraja Naik, Honnaiah Vijay Kumar, Vuppugundur Veena

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Novel series of phenothiazine derivatives obtained by the phenothiazine-aryl amines conjugates via acetyl group was described. The newly synthesized compounds were characterized by spectral and elemental analysis data. The antioxidant activity was assessed using two in vitro methods namely, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay and inhibition on human low density lipoprotein (LDL) oxidation assay. All the conjugates exhibited good antioxidant activity whereas, compound 2e having 4-amino-2-methoxyphenol moiety exhibited potent antioxidant activities in both the assays and was found more active than the butylated hydroxy anisole (BHA), a reference antioxidant.

Original languageEnglish (US)
Pages (from-to)786-794
Number of pages9
JournalDer Pharmacia Lettre
Volume4
Issue number3
StatePublished - Jul 24 2012

Keywords

  • 10-chloroacetylphenothiazine
  • Aryl amines
  • LDL oxidation
  • Phenothiazine
  • Radical scavenging activity

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