Novel peptide-peptide cooperation may transform feeding behavior

Abba J. Kastin, Weihong Pan, Victoria Akerstrom, Laszlo Hackler, Chuanfeng Wang, Catherine M. Kotz

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


There is need for a new approach to the suppression of feeding. Here, we show that two of the most potent endogenous satiety peptides interact in a novel way to cross the blood-brain barrier (BBB) and to suppress food intake. Combined peripheral administration of leptin and urocortin (UCN) significantly decreased food intake, whereas neither one showed an effect when given alone in the same doses. We further provide a mechanism whereby this novel cooperativity can occur by demonstrating that UCN, which by itself does not cross the BBB, can readily enter the brain by associating with leptin. Such a novel interaction between two peptides at the BBB opens new approaches for general study of the dynamic regulatory role of the BBB in brain-body communication as well as the specific study of obesity.

Original languageEnglish (US)
Pages (from-to)2189-2196
Number of pages8
Issue number12
StatePublished - Dec 1 2002

Bibliographical note

Funding Information:
Supported by NIH (DK54880 and AA12865) and the Department of Veterans Affairs.


  • Blood-brain barrier
  • Feeding behavior
  • Leptin
  • Peptide-peptide cooperation
  • Transport
  • Urocortin


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