Novel papillomavirus in a mallard duck with mesenchymal chondroid dermal tumors

Claire S. Rosenbaum, Arno Wünschmann, Anibal G Armien, Renee Schott, Vikash K Singh, Sunil K. Mor

Research output: Contribution to journalArticlepeer-review

Abstract

Papillomaviruses, which are epitheliotropic and may induce epithelial tumors, have been identified in several avian species, including ducks. An adult female mallard duck (Anas platyrhynchos) was admitted to a wildlife rehabilitation center with 2 beige, well-demarcated, firm masses: one in the subcutis under a wing, and the other on a digit of the right foot. After euthanasia, the masses were fixed in formalin for histologic examination. Both tumors had a lobular organization with cartilage cores surrounded by densely cellular interlacing bundles of spindle cells. Neoplastic chondroblasts in both masses, particularly the digital mass, contained basophilic intranuclear inclusion bodies, which consisted of assembly complexes of icosahedral virions of 44-nm diameter. Next-generation sequencing allowed whole genome assembly of a novel papillomavirus (Anas platyrhynchos papillomavirus 2) related most closely to Fulmarus glacialis papillomavirus 1 (59.49% nucleotide identity). Our case supports the observation that certain papillomaviruses can productively infect mesenchymal cells and induce neoplasia.

Original languageEnglish (US)
Pages (from-to)231-236
Number of pages6
JournalJournal of Veterinary Diagnostic Investigation
Volume34
Issue number2
DOIs
StatePublished - Mar 2022

Bibliographical note

Funding Information:
Claire Rosenbaum was supported from the Veterinary Diagnostic Laboratory and the Veterinary Summer Scholars Program, College of Veterinary Medicine, University of Minnesota. We thank Dean Muldoon for the electron microscopy preparations.

Publisher Copyright:
© The Author(s) 2022.

Keywords

  • cartilaginous differentiation
  • mallard ducks
  • mesenchymal tumor
  • papillomavirus
  • Animals, Wild
  • Animals
  • Papillomaviridae/genetics
  • Birds
  • Female
  • Ducks

PubMed: MeSH publication types

  • Journal Article

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