Novel methodologies for the synthesis of functionalized pyroglutamates

Srinivas Tekkam, M. A. Alam, Subash C. Jonnalagadda, Venkatram R Mereddy

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Alkylation of amino-acid derived iminoesters with Baylis-Hillman (BH) template based allyl bromides furnished α-methylene-β-substituted-pyroglutamates, while the corresponding alkylation with BH derived allylic acetates provided α-alkylidene-pyroglutamates. These methodologies have been applied in the synthesis of fused [3.2.0]-γ-lactam-β-lactones.

Original languageEnglish (US)
Pages (from-to)3219-3221
Number of pages3
JournalChemical Communications
Volume47
Issue number11
DOIs
StatePublished - Mar 1 2011

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