Novel Method Suggests Global Superiority of Short-Duration Antibiotics for Intra-abdominal Infections

Arthur R. Celestin; Stephen R. Odom; Konstantia Angelidou; Scott R. Evans; Raul Coimbra; Christopher A. Guidry; Joseph Cuschieri; Kaysie L. Banton; Patrick J. O'Neill; Reza Askari; Nicholas Namias; Therèse M. Duane; Jeffrey A. Claridge; E. Patchen Dellinger; Robert A. Sawyer; Charles H. Cook

doi:10.1093/cid/cix569

Novel Method Suggests Global Superiority of Short-Duration Antibiotics for Intra-abdominal Infections

Arthur R. Celestin
, Stephen R. Odom
, Konstantia Angelidou
, Scott R. Evans
, Raul Coimbra
, Christopher A. Guidry
, Joseph Cuschieri
, Kaysie L. Banton
, Patrick J. O'Neill
, Reza Askari
, Nicholas Namias
, Therèse M. Duane
, Jeffrey A. Claridge
, E. Patchen Dellinger
, Robert A. Sawyer
, Charles H. Cook

Surgery

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Desirability of outcome ranking and response adjusted for duration of antibiotic risk (DOOR/RADAR) are novel and innovative methods of evaluating data in antibiotic trials. We analyzed data from a noninferiority trial of short-course antimicrobial therapy for intra-abdominal infection (STOP-IT), and results suggest global superiority of short-duration therapy for intra-abdominal infections.

Original language	English (US)
Pages (from-to)	1577-1579
Number of pages	3
Journal	Clinical Infectious Diseases
Volume	65
Issue number	9
DOIs	https://doi.org/10.1093/cid/cix569
State	Published - Nov 1 2017

Bibliographical note

Publisher Copyright:
© 2017 The Author. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.

Keywords

antibiotic resistance
desirability of outcome ranking
duration of antibiotic therapy
intra-abdominal infection
surgical infection

Publisher link

10.1093/cid/cix569

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850039

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Celestin, A. R., Odom, S. R., Angelidou, K., Evans, S. R., Coimbra, R., Guidry, C. A., Cuschieri, J., Banton, K. L., O'Neill, P. J., Askari, R., Namias, N., Duane, T. M., Claridge, J. A., Dellinger, E. P., Sawyer, R. A., & Cook, C. H. (2017). Novel Method Suggests Global Superiority of Short-Duration Antibiotics for Intra-abdominal Infections. Clinical Infectious Diseases, 65(9), 1577-1579. https://doi.org/10.1093/cid/cix569

Celestin, AR, Odom, SR, Angelidou, K, Evans, SR, Coimbra, R, Guidry, CA, Cuschieri, J, Banton, KL, O'Neill, PJ, Askari, R, Namias, N, Duane, TM, Claridge, JA, Dellinger, EP, Sawyer, RA & Cook, CH 2017, 'Novel Method Suggests Global Superiority of Short-Duration Antibiotics for Intra-abdominal Infections', Clinical Infectious Diseases, vol. 65, no. 9, pp. 1577-1579. https://doi.org/10.1093/cid/cix569

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abstract = "Desirability of outcome ranking and response adjusted for duration of antibiotic risk (DOOR/RADAR) are novel and innovative methods of evaluating data in antibiotic trials. We analyzed data from a noninferiority trial of short-course antimicrobial therapy for intra-abdominal infection (STOP-IT), and results suggest global superiority of short-duration therapy for intra-abdominal infections.",

keywords = "antibiotic resistance, desirability of outcome ranking, duration of antibiotic therapy, intra-abdominal infection, surgical infection",

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AU - Cuschieri, Joseph

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AU - O'Neill, Patrick J.

AU - Askari, Reza

AU - Namias, Nicholas

AU - Duane, Therèse M.

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KW - desirability of outcome ranking

KW - duration of antibiotic therapy

KW - intra-abdominal infection

KW - surgical infection

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Novel Method Suggests Global Superiority of Short-Duration Antibiotics for Intra-abdominal Infections

Abstract

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Keywords

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