Background: Catheter ablation is associated with limited success rates in patients with persistent atrial fibrillation (AF). Currently, existing mapping systems fail to identify critical target sites for ablation. Recently, we proposed and validated several techniques (multiscale frequency [MSF], Shannon entropy [SE], kurtosis [Kt], and multiscale entropy [MSE]) to identify pivot point of rotors using ex-vivo optical mapping animal experiments. However, the performance of these techniques is unclear for the clinically recorded intracardiac electrograms (EGMs), due to the different nature of the signals. Objective: This study aims to evaluate the performance of MSF, MSE, SE, and Kt techniques to identify the pivot point of the rotor using unipolar and bipolar EGMs obtained from numerical simulations. Methods: Stationary and meandering rotors were simulated in a 2D human atria. The performances of new approaches were quantified by comparing the “true” core of the rotor with the core identified by the techniques. Also, the performances of all techniques were evaluated in the presence of noise, scar, and for the case of the multielectrode multispline and grid catheters. Results: Our results demonstrate that all the approaches are able to accurately identify the pivot point of both stationary and meandering rotors from both unipolar and bipolar EGMs. The presence of noise and scar tissue did not significantly affect the performance of the techniques. Finally, the core of the rotors was correctly identified for the case of multielectrode multispline and grid catheter simulations. Conclusion: The core of rotors can be successfully identified from EGMs using novel techniques; thus, providing motivation for future clinical implementations.
Bibliographical noteFunding Information:
This study was supported by the NSF DCSD 1662250 (Elena G. Tolkacheva) and NIH R01HL134791 (Elena G. Tolkacheva); IEM grants from the University of Minnesota (Elena G. Tolkacheva and Siva K. Mulpuru).
© 2021 Wiley Periodicals LLC
- Shannon entropy
- atrial fibrillation
- clinical limitations
- multiscale entropy
- multiscale frequency
- simulated intracardiac electrograms
PubMed: MeSH publication types
- Journal Article
- Research Support, N.I.H., Extramural
- Research Support, Non-U.S. Gov't
- Research Support, U.S. Gov't, Non-P.H.S.