Novel mapping techniques for rotor core detection using simulated intracardiac electrograms

Vasanth Ravikumar, Elizabeth Annoni, Preethy Parthiban, Sharon Zlochiver, Henri Roukoz, Siva K. Mulpuru, Elena G. Tolkacheva

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Background: Catheter ablation is associated with limited success rates in patients with persistent atrial fibrillation (AF). Currently, existing mapping systems fail to identify critical target sites for ablation. Recently, we proposed and validated several techniques (multiscale frequency [MSF], Shannon entropy [SE], kurtosis [Kt], and multiscale entropy [MSE]) to identify pivot point of rotors using ex-vivo optical mapping animal experiments. However, the performance of these techniques is unclear for the clinically recorded intracardiac electrograms (EGMs), due to the different nature of the signals. Objective: This study aims to evaluate the performance of MSF, MSE, SE, and Kt techniques to identify the pivot point of the rotor using unipolar and bipolar EGMs obtained from numerical simulations. Methods: Stationary and meandering rotors were simulated in a 2D human atria. The performances of new approaches were quantified by comparing the “true” core of the rotor with the core identified by the techniques. Also, the performances of all techniques were evaluated in the presence of noise, scar, and for the case of the multielectrode multispline and grid catheters. Results: Our results demonstrate that all the approaches are able to accurately identify the pivot point of both stationary and meandering rotors from both unipolar and bipolar EGMs. The presence of noise and scar tissue did not significantly affect the performance of the techniques. Finally, the core of the rotors was correctly identified for the case of multielectrode multispline and grid catheter simulations. Conclusion: The core of rotors can be successfully identified from EGMs using novel techniques; thus, providing motivation for future clinical implementations.

Original languageEnglish (US)
Pages (from-to)1268-1280
Number of pages13
JournalJournal of cardiovascular electrophysiology
Issue number5
StatePublished - May 2021

Bibliographical note

Funding Information:
This study was supported by the NSF DCSD 1662250 (Elena G. Tolkacheva) and NIH R01HL134791 (Elena G. Tolkacheva); IEM grants from the University of Minnesota (Elena G. Tolkacheva and Siva K. Mulpuru).

Publisher Copyright:
© 2021 Wiley Periodicals LLC


  • Shannon entropy
  • atrial fibrillation
  • clinical limitations
  • kurtosis
  • multiscale entropy
  • multiscale frequency
  • rotors
  • simulated intracardiac electrograms


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