Novel Magnetic Resonance Imaging Contrasts for Monitoring Response to Gene Therapy in Rat Glioma

Olli H.J. Gröhn; Piia K. Valonen; Kimmo K. Lehtimäki; Tuula H. Väisänen; Mikko I. Kettunen; Seppo Ylä-Herttuala; Risto A. Kauppinen; Michael Garwood

Novel Magnetic Resonance Imaging Contrasts for Monitoring Response to Gene Therapy in Rat Glioma

Olli H.J. Gröhn
, Piia K. Valonen
, Kimmo K. Lehtimäki
, Tuula H. Väisänen
, Mikko I. Kettunen
, Seppo Ylä-Herttuala
, Risto A. Kauppinen
, Michael Garwood

Research output: Contribution to journal › Article › peer-review

Abstract

Magnetic resonance imaging relaxation times, T_1ρ and Carr-Purcell T₂ (CP-T₂), were measured in a glioma herpes simplex virus-thymidine kinase gene therapy model. In treated tumors with >50% cell death by histology, T_1ρ and CP-T₂ measured with short spacing (τ_CP) between centers of adiabatic refocusing pulses showed similar enhanced sensitivity to cytotoxic cell damage over CP-T₂ measured with long τ_CP (long-τ _CP T₂: 54.3 ± 0.7 and 55.4 ± 1.2 ms, P = 0.30; short-τ_CP T₂: 61.3 ± 1.0 and 64.2 ± 1.1 ms, P < 0.05 before and day 2 of treatment, respectively). Without treatment, long-τ_CP T₂ provided the most pronounced contrast between tumor and normal cerebral tissue. These data demonstrate that endogenous T₂ contrast can be modulated and extended in a manner likely to be clinically important.

Original language	English (US)
Pages (from-to)	7571-7574
Number of pages	4
Journal	Cancer Research
Volume	63
Issue number	22
State	Published - Nov 15 2003

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Find It

Find It at U of M Libraries

Cite this

@article{30fa67d69a434551b15b323f9d7f5c87,

title = "Novel Magnetic Resonance Imaging Contrasts for Monitoring Response to Gene Therapy in Rat Glioma",

abstract = "Magnetic resonance imaging relaxation times, T1ρ and Carr-Purcell T2 (CP-T2), were measured in a glioma herpes simplex virus-thymidine kinase gene therapy model. In treated tumors with >50\% cell death by histology, T1ρ and CP-T2 measured with short spacing (τCP) between centers of adiabatic refocusing pulses showed similar enhanced sensitivity to cytotoxic cell damage over CP-T2 measured with long τCP (long-τ CP T2: 54.3 ± 0.7 and 55.4 ± 1.2 ms, P = 0.30; short-τCP T2: 61.3 ± 1.0 and 64.2 ± 1.1 ms, P < 0.05 before and day 2 of treatment, respectively). Without treatment, long-τCP T2 provided the most pronounced contrast between tumor and normal cerebral tissue. These data demonstrate that endogenous T2 contrast can be modulated and extended in a manner likely to be clinically important.",

author = "Gr{\"o}hn, \{Olli H.J.\} and Valonen, \{Piia K.\} and Lehtim{\"a}ki, \{Kimmo K.\} and V{\"a}is{\"a}nen, \{Tuula H.\} and Kettunen, \{Mikko I.\} and Seppo Yl{\"a}-Herttuala and Kauppinen, \{Risto A.\} and Michael Garwood",

year = "2003",

month = nov,

day = "15",

language = "English (US)",

volume = "63",

pages = "7571--7574",

journal = "Cancer Research",

issn = "0008-5472",

publisher = "American Association for Cancer Research Inc.",

number = "22",

}

TY - JOUR

T1 - Novel Magnetic Resonance Imaging Contrasts for Monitoring Response to Gene Therapy in Rat Glioma

AU - Gröhn, Olli H.J.

AU - Valonen, Piia K.

AU - Lehtimäki, Kimmo K.

AU - Väisänen, Tuula H.

AU - Kettunen, Mikko I.

AU - Ylä-Herttuala, Seppo

AU - Kauppinen, Risto A.

AU - Garwood, Michael

PY - 2003/11/15

Y1 - 2003/11/15

N2 - Magnetic resonance imaging relaxation times, T1ρ and Carr-Purcell T2 (CP-T2), were measured in a glioma herpes simplex virus-thymidine kinase gene therapy model. In treated tumors with >50% cell death by histology, T1ρ and CP-T2 measured with short spacing (τCP) between centers of adiabatic refocusing pulses showed similar enhanced sensitivity to cytotoxic cell damage over CP-T2 measured with long τCP (long-τ CP T2: 54.3 ± 0.7 and 55.4 ± 1.2 ms, P = 0.30; short-τCP T2: 61.3 ± 1.0 and 64.2 ± 1.1 ms, P < 0.05 before and day 2 of treatment, respectively). Without treatment, long-τCP T2 provided the most pronounced contrast between tumor and normal cerebral tissue. These data demonstrate that endogenous T2 contrast can be modulated and extended in a manner likely to be clinically important.

AB - Magnetic resonance imaging relaxation times, T1ρ and Carr-Purcell T2 (CP-T2), were measured in a glioma herpes simplex virus-thymidine kinase gene therapy model. In treated tumors with >50% cell death by histology, T1ρ and CP-T2 measured with short spacing (τCP) between centers of adiabatic refocusing pulses showed similar enhanced sensitivity to cytotoxic cell damage over CP-T2 measured with long τCP (long-τ CP T2: 54.3 ± 0.7 and 55.4 ± 1.2 ms, P = 0.30; short-τCP T2: 61.3 ± 1.0 and 64.2 ± 1.1 ms, P < 0.05 before and day 2 of treatment, respectively). Without treatment, long-τCP T2 provided the most pronounced contrast between tumor and normal cerebral tissue. These data demonstrate that endogenous T2 contrast can be modulated and extended in a manner likely to be clinically important.

UR - https://www.scopus.com/pages/publications/18744417684

UR - https://www.scopus.com/pages/publications/18744417684#tab=citedBy

M3 - Article

C2 - 14633668

AN - SCOPUS:18744417684

SN - 0008-5472

VL - 63

SP - 7571

EP - 7574

JO - Cancer Research

JF - Cancer Research

IS - 22

ER -

Novel Magnetic Resonance Imaging Contrasts for Monitoring Response to Gene Therapy in Rat Glioma

Abstract

UN SDGs

Find It

Other files and links

Fingerprint

Cite this