Novel Magnetic Resonance Imaging Contrasts for Monitoring Response to Gene Therapy in Rat Glioma

Olli H.J. Gröhn; Piia K. Valonen; Kimmo K. Lehtimäki; Tuula H. Väisänen; Mikko I. Kettunen; Seppo Ylä-Herttuala; Risto A. Kauppinen; Michael Garwood

Novel Magnetic Resonance Imaging Contrasts for Monitoring Response to Gene Therapy in Rat Glioma

Olli H.J. Gröhn, Piia K. Valonen, Kimmo K. Lehtimäki, Tuula H. Väisänen, Mikko I. Kettunen, Seppo Ylä-Herttuala, Risto A. Kauppinen, Michael Garwood

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Magnetic resonance imaging relaxation times, T_1ρ and Carr-Purcell T₂ (CP-T₂), were measured in a glioma herpes simplex virus-thymidine kinase gene therapy model. In treated tumors with >50% cell death by histology, T_1ρ and CP-T₂ measured with short spacing (τ_CP) between centers of adiabatic refocusing pulses showed similar enhanced sensitivity to cytotoxic cell damage over CP-T₂ measured with long τ_CP (long-τ _CP T₂: 54.3 ± 0.7 and 55.4 ± 1.2 ms, P = 0.30; short-τ_CP T₂: 61.3 ± 1.0 and 64.2 ± 1.1 ms, P < 0.05 before and day 2 of treatment, respectively). Without treatment, long-τ_CP T₂ provided the most pronounced contrast between tumor and normal cerebral tissue. These data demonstrate that endogenous T₂ contrast can be modulated and extended in a manner likely to be clinically important.

Original language	English (US)
Pages (from-to)	7571-7574
Number of pages	4
Journal	Cancer Research
Volume	63
Issue number	22
State	Published - Nov 15 2003

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Find It

Find It at U of M Libraries

Cite this

@article{30fa67d69a434551b15b323f9d7f5c87,

title = "Novel Magnetic Resonance Imaging Contrasts for Monitoring Response to Gene Therapy in Rat Glioma",

abstract = "Magnetic resonance imaging relaxation times, T1ρ and Carr-Purcell T2 (CP-T2), were measured in a glioma herpes simplex virus-thymidine kinase gene therapy model. In treated tumors with >50% cell death by histology, T1ρ and CP-T2 measured with short spacing (τCP) between centers of adiabatic refocusing pulses showed similar enhanced sensitivity to cytotoxic cell damage over CP-T2 measured with long τCP (long-τ CP T2: 54.3 ± 0.7 and 55.4 ± 1.2 ms, P = 0.30; short-τCP T2: 61.3 ± 1.0 and 64.2 ± 1.1 ms, P < 0.05 before and day 2 of treatment, respectively). Without treatment, long-τCP T2 provided the most pronounced contrast between tumor and normal cerebral tissue. These data demonstrate that endogenous T2 contrast can be modulated and extended in a manner likely to be clinically important.",

author = "Gr{\"o}hn, {Olli H.J.} and Valonen, {Piia K.} and Lehtim{\"a}ki, {Kimmo K.} and V{\"a}is{\"a}nen, {Tuula H.} and Kettunen, {Mikko I.} and Seppo Yl{\"a}-Herttuala and Kauppinen, {Risto A.} and Michael Garwood",

year = "2003",

month = nov,

day = "15",

language = "English (US)",

volume = "63",

pages = "7571--7574",

journal = "Cancer Research",

issn = "0008-5472",

publisher = "American Association for Cancer Research Inc.",

number = "22",

}

TY - JOUR

T1 - Novel Magnetic Resonance Imaging Contrasts for Monitoring Response to Gene Therapy in Rat Glioma

AU - Gröhn, Olli H.J.

AU - Valonen, Piia K.

AU - Lehtimäki, Kimmo K.

AU - Väisänen, Tuula H.

AU - Kettunen, Mikko I.

AU - Ylä-Herttuala, Seppo

AU - Kauppinen, Risto A.

AU - Garwood, Michael

PY - 2003/11/15

Y1 - 2003/11/15

N2 - Magnetic resonance imaging relaxation times, T1ρ and Carr-Purcell T2 (CP-T2), were measured in a glioma herpes simplex virus-thymidine kinase gene therapy model. In treated tumors with >50% cell death by histology, T1ρ and CP-T2 measured with short spacing (τCP) between centers of adiabatic refocusing pulses showed similar enhanced sensitivity to cytotoxic cell damage over CP-T2 measured with long τCP (long-τ CP T2: 54.3 ± 0.7 and 55.4 ± 1.2 ms, P = 0.30; short-τCP T2: 61.3 ± 1.0 and 64.2 ± 1.1 ms, P < 0.05 before and day 2 of treatment, respectively). Without treatment, long-τCP T2 provided the most pronounced contrast between tumor and normal cerebral tissue. These data demonstrate that endogenous T2 contrast can be modulated and extended in a manner likely to be clinically important.

AB - Magnetic resonance imaging relaxation times, T1ρ and Carr-Purcell T2 (CP-T2), were measured in a glioma herpes simplex virus-thymidine kinase gene therapy model. In treated tumors with >50% cell death by histology, T1ρ and CP-T2 measured with short spacing (τCP) between centers of adiabatic refocusing pulses showed similar enhanced sensitivity to cytotoxic cell damage over CP-T2 measured with long τCP (long-τ CP T2: 54.3 ± 0.7 and 55.4 ± 1.2 ms, P = 0.30; short-τCP T2: 61.3 ± 1.0 and 64.2 ± 1.1 ms, P < 0.05 before and day 2 of treatment, respectively). Without treatment, long-τCP T2 provided the most pronounced contrast between tumor and normal cerebral tissue. These data demonstrate that endogenous T2 contrast can be modulated and extended in a manner likely to be clinically important.

UR - http://www.scopus.com/inward/record.url?scp=18744417684&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=18744417684&partnerID=8YFLogxK

M3 - Article

C2 - 14633668

AN - SCOPUS:18744417684

SN - 0008-5472

VL - 63

SP - 7571

EP - 7574

JO - Cancer Research

JF - Cancer Research

IS - 22

ER -

Novel Magnetic Resonance Imaging Contrasts for Monitoring Response to Gene Therapy in Rat Glioma

Abstract

UN SDGs

Find It

Other files and links

Fingerprint

Cite this