The characteristics of a voltage- and time-dependent inward rectifying current were examined with voltage clamp techniques in crayfish muscle. The inward current, carried by K+, was activated by hyperpolarization. Although this inward current increased with the extracellular K+ concentration ([K+]o), the voltage-dependence of the underlying conductance was independent of [K+]o. The current was unaffected by Cs+ and Ba2+, but was blocked by low concentrations of Cd2+. Therefore, this inward rectifier is different than previously described ones.
Bibliographical noteFunding Information:
We would like to thank Drs. M. Gola and C.E Stevens for their suggestions. This work was supported by DGICYT grant to W.B. A.A. is a CajaMadrid fellow.
- Anomalous rectification
- Crayfish muscle
- Hyperpolarization-activated current
- Inward rectifier
- K current