Novel inward rectifier blocked by Cd2+ in crayfish muscle

Alfonso Araque, Washington Buño

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The characteristics of a voltage- and time-dependent inward rectifying current were examined with voltage clamp techniques in crayfish muscle. The inward current, carried by K+, was activated by hyperpolarization. Although this inward current increased with the extracellular K+ concentration ([K+]o), the voltage-dependence of the underlying conductance was independent of [K+]o. The current was unaffected by Cs+ and Ba2+, but was blocked by low concentrations of Cd2+. Therefore, this inward rectifier is different than previously described ones.

Original languageEnglish (US)
Pages (from-to)321-324
Number of pages4
JournalBrain Research
Volume563
Issue number1-2
DOIs
StatePublished - Nov 1 1991

Bibliographical note

Funding Information:
We would like to thank Drs. M. Gola and C.E Stevens for their suggestions. This work was supported by DGICYT grant to W.B. A.A. is a CajaMadrid fellow.

Keywords

  • Anomalous rectification
  • Cd-blockade
  • Crayfish muscle
  • Hyperpolarization-activated current
  • Inward rectifier
  • K current

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