Novel Imaging Technologies for Accurate Assessment of Cardiac Allograft Performance

Manuela Lopera Higuita, Rohil Jain, Asishana A. Osho, S. Alireza Rabi, Timothy L. Pruett, Richard N. Pierson, Paul A. Iaizzo, Shannon N. Tessier

Research output: Contribution to journalReview articlepeer-review


Purpose of the Review: The current lack of objective and quantitative assessment techniques to determine cardiac graft relative viability results in risk-averse decision-making, which negatively impact the utilization of cardiac grafts. The purpose of this review is to highlight the current deficiencies in cardiac allograft assessment before focusing on novel cardiac assessment techniques that exploit conventional and emerging imaging modalities, including ultrasound, magnetic resonance, and spectroscopy. Recent Findings: Extensive work is ongoing by the scientific community to identify improved objective metrics and tools for cardiac graft assessment, with the goal to safely increasing the number and proportion of hearts accepted for transplantation. Summary: This review briefly discusses the in situ and ex vivo tools currently available for clinical organ assessment, before focusing on the individual capabilities of ultrasound, magnetic resonance, and spectroscopy to provide insightful, non-invasive information regarding cardiac graft functional and metabolic status that may be used to predict outcome after transplantation.

Original languageEnglish (US)
Pages (from-to)100-109
Number of pages10
JournalCurrent Transplantation Reports
Issue number3
StatePublished - Sep 2023

Bibliographical note

Funding Information:
We gratefully acknowledge funding to SNT from the US National Institute of Health (K99/R00 HL1431149; R01HL157803; R01DK134590), American Heart Association (18CDA34110049), Harvard Medical School Eleanor and Miles Shore Fellowship, and the Claflin Distinguished Scholar Award on behalf of the MGH Executive Committee on Research. Further, we acknowledge the National Science Foundation under Grant No. EEC 1941543 (SNT, PAI, and TLP). We thankfully acknowledge support provided by the Fund for Medical Discovery (FMD) Clinical Research Fellowship awarded to RJ by the Executive Committee on Research at the Massachusetts General Hospital, and grant support provided by US National Institute of Health (U19 AI090959 and UO1 AI153612) to RNP. Finally, we would like to acknowledge each family’s immense loss, and sincerely thank these families and the organ donors for their generous gift of life.

Publisher Copyright:
© 2023, The Author(s).


  • Heart assessment
  • Heart transplant
  • Imaging techniques
  • Magnetic resonance imaging
  • Spectroscopy
  • Ultrasound


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