Novel Imaging Technologies for Accurate Assessment of Cardiac Allograft Performance

Manuela Lopera Higuita; Rohil Jain; Asishana A. Osho; S. Alireza Rabi; Timothy L. Pruett; Richard N. Pierson; Paul A. Iaizzo; Shannon N. Tessier

doi:10.1007/s40472-023-00400-w

Novel Imaging Technologies for Accurate Assessment of Cardiac Allograft Performance

Manuela Lopera Higuita, Rohil Jain, Asishana A. Osho, S. Alireza Rabi, Timothy L. Pruett, Richard N. Pierson, Paul A. Iaizzo, Shannon N. Tessier

Surgery

Research output: Contribution to journal › Review article › peer-review

Abstract

Purpose of the Review: The current lack of objective and quantitative assessment techniques to determine cardiac graft relative viability results in risk-averse decision-making, which negatively impact the utilization of cardiac grafts. The purpose of this review is to highlight the current deficiencies in cardiac allograft assessment before focusing on novel cardiac assessment techniques that exploit conventional and emerging imaging modalities, including ultrasound, magnetic resonance, and spectroscopy. Recent Findings: Extensive work is ongoing by the scientific community to identify improved objective metrics and tools for cardiac graft assessment, with the goal to safely increasing the number and proportion of hearts accepted for transplantation. Summary: This review briefly discusses the in situ and ex vivo tools currently available for clinical organ assessment, before focusing on the individual capabilities of ultrasound, magnetic resonance, and spectroscopy to provide insightful, non-invasive information regarding cardiac graft functional and metabolic status that may be used to predict outcome after transplantation.

Original language	English (US)
Pages (from-to)	100-109
Number of pages	10
Journal	Current Transplantation Reports
Volume	10
Issue number	3
DOIs	https://doi.org/10.1007/s40472-023-00400-w
State	Published - Sep 2023

Bibliographical note

Funding Information:
We gratefully acknowledge funding to SNT from the US National Institute of Health (K99/R00 HL1431149; R01HL157803; R01DK134590), American Heart Association (18CDA34110049), Harvard Medical School Eleanor and Miles Shore Fellowship, and the Claflin Distinguished Scholar Award on behalf of the MGH Executive Committee on Research. Further, we acknowledge the National Science Foundation under Grant No. EEC 1941543 (SNT, PAI, and TLP). We thankfully acknowledge support provided by the Fund for Medical Discovery (FMD) Clinical Research Fellowship awarded to RJ by the Executive Committee on Research at the Massachusetts General Hospital, and grant support provided by US National Institute of Health (U19 AI090959 and UO1 AI153612) to RNP. Finally, we would like to acknowledge each family’s immense loss, and sincerely thank these families and the organ donors for their generous gift of life.

Publisher Copyright:
© 2023, The Author(s).

Keywords

Heart assessment
Heart transplant
Imaging techniques
Magnetic resonance imaging
Spectroscopy
Ultrasound

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10.1007/s40472-023-00400-w

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title = "Novel Imaging Technologies for Accurate Assessment of Cardiac Allograft Performance",

abstract = "Purpose of the Review: The current lack of objective and quantitative assessment techniques to determine cardiac graft relative viability results in risk-averse decision-making, which negatively impact the utilization of cardiac grafts. The purpose of this review is to highlight the current deficiencies in cardiac allograft assessment before focusing on novel cardiac assessment techniques that exploit conventional and emerging imaging modalities, including ultrasound, magnetic resonance, and spectroscopy. Recent Findings: Extensive work is ongoing by the scientific community to identify improved objective metrics and tools for cardiac graft assessment, with the goal to safely increasing the number and proportion of hearts accepted for transplantation. Summary: This review briefly discusses the in situ and ex vivo tools currently available for clinical organ assessment, before focusing on the individual capabilities of ultrasound, magnetic resonance, and spectroscopy to provide insightful, non-invasive information regarding cardiac graft functional and metabolic status that may be used to predict outcome after transplantation.",

keywords = "Heart assessment, Heart transplant, Imaging techniques, Magnetic resonance imaging, Spectroscopy, Ultrasound",

author = "Higuita, {Manuela Lopera} and Rohil Jain and Osho, {Asishana A.} and Rabi, {S. Alireza} and Pruett, {Timothy L.} and Pierson, {Richard N.} and Iaizzo, {Paul A.} and Tessier, {Shannon N.}",

note = "Funding Information: We gratefully acknowledge funding to SNT from the US National Institute of Health (K99/R00 HL1431149; R01HL157803; R01DK134590), American Heart Association (18CDA34110049), Harvard Medical School Eleanor and Miles Shore Fellowship, and the Claflin Distinguished Scholar Award on behalf of the MGH Executive Committee on Research. Further, we acknowledge the National Science Foundation under Grant No. EEC 1941543 (SNT, PAI, and TLP). We thankfully acknowledge support provided by the Fund for Medical Discovery (FMD) Clinical Research Fellowship awarded to RJ by the Executive Committee on Research at the Massachusetts General Hospital, and grant support provided by US National Institute of Health (U19 AI090959 and UO1 AI153612) to RNP. Finally, we would like to acknowledge each family{\textquoteright}s immense loss, and sincerely thank these families and the organ donors for their generous gift of life. Publisher Copyright: {\textcopyright} 2023, The Author(s).",

year = "2023",

month = sep,

doi = "10.1007/s40472-023-00400-w",

language = "English (US)",

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journal = "Current Transplantation Reports",

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AU - Higuita, Manuela Lopera

AU - Jain, Rohil

AU - Osho, Asishana A.

AU - Rabi, S. Alireza

AU - Pruett, Timothy L.

AU - Pierson, Richard N.

AU - Iaizzo, Paul A.

AU - Tessier, Shannon N.

N1 - Funding Information: We gratefully acknowledge funding to SNT from the US National Institute of Health (K99/R00 HL1431149; R01HL157803; R01DK134590), American Heart Association (18CDA34110049), Harvard Medical School Eleanor and Miles Shore Fellowship, and the Claflin Distinguished Scholar Award on behalf of the MGH Executive Committee on Research. Further, we acknowledge the National Science Foundation under Grant No. EEC 1941543 (SNT, PAI, and TLP). We thankfully acknowledge support provided by the Fund for Medical Discovery (FMD) Clinical Research Fellowship awarded to RJ by the Executive Committee on Research at the Massachusetts General Hospital, and grant support provided by US National Institute of Health (U19 AI090959 and UO1 AI153612) to RNP. Finally, we would like to acknowledge each family’s immense loss, and sincerely thank these families and the organ donors for their generous gift of life. Publisher Copyright: © 2023, The Author(s).

PY - 2023/9

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N2 - Purpose of the Review: The current lack of objective and quantitative assessment techniques to determine cardiac graft relative viability results in risk-averse decision-making, which negatively impact the utilization of cardiac grafts. The purpose of this review is to highlight the current deficiencies in cardiac allograft assessment before focusing on novel cardiac assessment techniques that exploit conventional and emerging imaging modalities, including ultrasound, magnetic resonance, and spectroscopy. Recent Findings: Extensive work is ongoing by the scientific community to identify improved objective metrics and tools for cardiac graft assessment, with the goal to safely increasing the number and proportion of hearts accepted for transplantation. Summary: This review briefly discusses the in situ and ex vivo tools currently available for clinical organ assessment, before focusing on the individual capabilities of ultrasound, magnetic resonance, and spectroscopy to provide insightful, non-invasive information regarding cardiac graft functional and metabolic status that may be used to predict outcome after transplantation.

AB - Purpose of the Review: The current lack of objective and quantitative assessment techniques to determine cardiac graft relative viability results in risk-averse decision-making, which negatively impact the utilization of cardiac grafts. The purpose of this review is to highlight the current deficiencies in cardiac allograft assessment before focusing on novel cardiac assessment techniques that exploit conventional and emerging imaging modalities, including ultrasound, magnetic resonance, and spectroscopy. Recent Findings: Extensive work is ongoing by the scientific community to identify improved objective metrics and tools for cardiac graft assessment, with the goal to safely increasing the number and proportion of hearts accepted for transplantation. Summary: This review briefly discusses the in situ and ex vivo tools currently available for clinical organ assessment, before focusing on the individual capabilities of ultrasound, magnetic resonance, and spectroscopy to provide insightful, non-invasive information regarding cardiac graft functional and metabolic status that may be used to predict outcome after transplantation.

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KW - Spectroscopy

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Novel Imaging Technologies for Accurate Assessment of Cardiac Allograft Performance

Abstract

Bibliographical note

Keywords

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