Novel Göttingen Miniswine Model of Heart Failure With Preserved Ejection Fraction Integrating Multiple Comorbidities

Thomas E. Sharp; Amy L. Scarborough; Zhen Li; David J. Polhemus; Hunter A. Hidalgo; Jeffery D. Schumacher; Timothy R. Matsuura; J. Stephen Jenkins; Daniel P. Kelly; Traci T. Goodchild; David J. Lefer

doi:10.1016/j.jacbts.2020.11.012

Novel Göttingen Miniswine Model of Heart Failure With Preserved Ejection Fraction Integrating Multiple Comorbidities

Thomas E. Sharp
, Amy L. Scarborough
, Zhen Li
, David J. Polhemus
, Hunter A. Hidalgo
, Jeffery D. Schumacher
, Timothy R. Matsuura
, J. Stephen Jenkins
, Daniel P. Kelly
, Traci T. Goodchild
, David J. Lefer

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

A lack of preclinical large animal models of heart failure with preserved ejection fraction (HFpEF) that recapitulate this comorbid-laden syndrome has led to the inability to tease out mechanistic insights and to test novel therapeutic strategies. This study developed a large animal model that integrated multiple comorbid determinants of HFpEF in a miniswine breed that exhibited sensitivity to obesity, metabolic syndrome, and vascular disease with overt clinical signs of heart failure. The combination of a Western diet and 11-deoxycorticosterone acetate salt−induced hypertension in the Göttingen miniswine led to the development of a novel large animal model of HFpEF that exhibited multiorgan involvement and a full spectrum of comorbidities associated with human HFpEF.

Original language	English (US)
Pages (from-to)	154-170
Number of pages	17
Journal	JACC: Basic to Translational Science
Volume	6
Issue number	2
DOIs	https://doi.org/10.1016/j.jacbts.2020.11.012
State	Published - Feb 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2021 The Authors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

animal models of human disease
heart failure with preserved ejection fraction
hypertension
metabolic syndrome
obesity

Publisher link

10.1016/j.jacbts.2020.11.012

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Sharp, T. E., Scarborough, A. L., Li, Z., Polhemus, D. J., Hidalgo, H. A., Schumacher, J. D., Matsuura, T. R., Jenkins, J. S., Kelly, D. P., Goodchild, T. T., & Lefer, D. J. (2021). Novel Göttingen Miniswine Model of Heart Failure With Preserved Ejection Fraction Integrating Multiple Comorbidities. JACC: Basic to Translational Science, 6(2), 154-170. https://doi.org/10.1016/j.jacbts.2020.11.012

Sharp, TE, Scarborough, AL, Li, Z, Polhemus, DJ, Hidalgo, HA, Schumacher, JD, Matsuura, TR, Jenkins, JS, Kelly, DP, Goodchild, TT & Lefer, DJ 2021, 'Novel Göttingen Miniswine Model of Heart Failure With Preserved Ejection Fraction Integrating Multiple Comorbidities', JACC: Basic to Translational Science, vol. 6, no. 2, pp. 154-170. https://doi.org/10.1016/j.jacbts.2020.11.012

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title = "Novel G{\"o}ttingen Miniswine Model of Heart Failure With Preserved Ejection Fraction Integrating Multiple Comorbidities",

abstract = "A lack of preclinical large animal models of heart failure with preserved ejection fraction (HFpEF) that recapitulate this comorbid-laden syndrome has led to the inability to tease out mechanistic insights and to test novel therapeutic strategies. This study developed a large animal model that integrated multiple comorbid determinants of HFpEF in a miniswine breed that exhibited sensitivity to obesity, metabolic syndrome, and vascular disease with overt clinical signs of heart failure. The combination of a Western diet and 11-deoxycorticosterone acetate salt−induced hypertension in the G{\"o}ttingen miniswine led to the development of a novel large animal model of HFpEF that exhibited multiorgan involvement and a full spectrum of comorbidities associated with human HFpEF.",

keywords = "animal models of human disease, heart failure with preserved ejection fraction, hypertension, metabolic syndrome, obesity",

author = "Sharp, \{Thomas E.\} and Scarborough, \{Amy L.\} and Zhen Li and Polhemus, \{David J.\} and Hidalgo, \{Hunter A.\} and Schumacher, \{Jeffery D.\} and Matsuura, \{Timothy R.\} and Jenkins, \{J. Stephen\} and Kelly, \{Daniel P.\} and Goodchild, \{Traci T.\} and Lefer, \{David J.\}",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors",

year = "2021",

month = feb,

doi = "10.1016/j.jacbts.2020.11.012",

language = "English (US)",

volume = "6",

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AU - Hidalgo, Hunter A.

AU - Schumacher, Jeffery D.

AU - Matsuura, Timothy R.

AU - Jenkins, J. Stephen

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KW - animal models of human disease

KW - heart failure with preserved ejection fraction

KW - hypertension

KW - metabolic syndrome

KW - obesity

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Novel Göttingen Miniswine Model of Heart Failure With Preserved Ejection Fraction Integrating Multiple Comorbidities

Abstract

Bibliographical note

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Keywords

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