Novel Göttingen Miniswine Model of Heart Failure With Preserved Ejection Fraction Integrating Multiple Comorbidities

Thomas E. Sharp; Amy L. Scarborough; Zhen Li; David J. Polhemus; Hunter A. Hidalgo; Jeffery D. Schumacher; Timothy R. Matsuura; J. Stephen Jenkins; Daniel P. Kelly; Traci T. Goodchild; David J. Lefer

doi:10.1016/j.jacbts.2020.11.012

Novel Göttingen Miniswine Model of Heart Failure With Preserved Ejection Fraction Integrating Multiple Comorbidities

Thomas E. Sharp, Amy L. Scarborough, Zhen Li, David J. Polhemus, Hunter A. Hidalgo, Jeffery D. Schumacher, Timothy R. Matsuura, J. Stephen Jenkins, Daniel P. Kelly, Traci T. Goodchild, David J. Lefer

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

A lack of preclinical large animal models of heart failure with preserved ejection fraction (HFpEF) that recapitulate this comorbid-laden syndrome has led to the inability to tease out mechanistic insights and to test novel therapeutic strategies. This study developed a large animal model that integrated multiple comorbid determinants of HFpEF in a miniswine breed that exhibited sensitivity to obesity, metabolic syndrome, and vascular disease with overt clinical signs of heart failure. The combination of a Western diet and 11-deoxycorticosterone acetate salt−induced hypertension in the Göttingen miniswine led to the development of a novel large animal model of HFpEF that exhibited multiorgan involvement and a full spectrum of comorbidities associated with human HFpEF.

Original language	English (US)
Pages (from-to)	154-170
Number of pages	17
Journal	JACC: Basic to Translational Science
Volume	6
Issue number	2
DOIs	https://doi.org/10.1016/j.jacbts.2020.11.012
State	Published - Feb 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2021 The Authors

Keywords

animal models of human disease
heart failure with preserved ejection fraction
hypertension
metabolic syndrome
obesity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jacbts.2020.11.012

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Sharp, T. E., Scarborough, A. L., Li, Z., Polhemus, D. J., Hidalgo, H. A., Schumacher, J. D., Matsuura, T. R., Jenkins, J. S., Kelly, D. P., Goodchild, T. T., & Lefer, D. J. (2021). Novel Göttingen Miniswine Model of Heart Failure With Preserved Ejection Fraction Integrating Multiple Comorbidities. JACC: Basic to Translational Science, 6(2), 154-170. https://doi.org/10.1016/j.jacbts.2020.11.012

Sharp, TE, Scarborough, AL, Li, Z, Polhemus, DJ, Hidalgo, HA, Schumacher, JD, Matsuura, TR, Jenkins, JS, Kelly, DP, Goodchild, TT & Lefer, DJ 2021, 'Novel Göttingen Miniswine Model of Heart Failure With Preserved Ejection Fraction Integrating Multiple Comorbidities', JACC: Basic to Translational Science, vol. 6, no. 2, pp. 154-170. https://doi.org/10.1016/j.jacbts.2020.11.012

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abstract = "A lack of preclinical large animal models of heart failure with preserved ejection fraction (HFpEF) that recapitulate this comorbid-laden syndrome has led to the inability to tease out mechanistic insights and to test novel therapeutic strategies. This study developed a large animal model that integrated multiple comorbid determinants of HFpEF in a miniswine breed that exhibited sensitivity to obesity, metabolic syndrome, and vascular disease with overt clinical signs of heart failure. The combination of a Western diet and 11-deoxycorticosterone acetate salt−induced hypertension in the G{\"o}ttingen miniswine led to the development of a novel large animal model of HFpEF that exhibited multiorgan involvement and a full spectrum of comorbidities associated with human HFpEF.",

keywords = "animal models of human disease, heart failure with preserved ejection fraction, hypertension, metabolic syndrome, obesity",

author = "Sharp, {Thomas E.} and Scarborough, {Amy L.} and Zhen Li and Polhemus, {David J.} and Hidalgo, {Hunter A.} and Schumacher, {Jeffery D.} and Matsuura, {Timothy R.} and Jenkins, {J. Stephen} and Kelly, {Daniel P.} and Goodchild, {Traci T.} and Lefer, {David J.}",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors",

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doi = "10.1016/j.jacbts.2020.11.012",

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Novel Göttingen Miniswine Model of Heart Failure With Preserved Ejection Fraction Integrating Multiple Comorbidities

Abstract

Bibliographical note

Keywords

UN SDGs

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