Novel form of spreading acidification and depression in the cerebellar cortex demonstrated by neutral red optical imaging

G. Chen, C. L. Hanson, R. L. Dunbar, T. J. Ebner

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

A novel form of spreading acidification and depression in the rat cerebellar cortex was imaged in vivo using the pH-sensitive dye, Neutral red. Surface stimulation evoked an initial beam of increased fluorescence (i.e., decreased pH) that spread rostrally and caudally across the folium and into neighboring folia. A transient but marked suppression in the excitability of the parallel fiber-Purkinje cell circuitry accompanied the spread. Characteristics differentiating this phenomenon from the spreading depression of Leao include: high speed of propagation on the surface (average of 450 μm/s), stable extracellular DC potential, no change in blood vessel diameter, and repeatability at short intervals. This propagating acidification constitutes a previously unknown class of neuronal processing in the cerebellar cortex.

Original languageEnglish (US)
Pages (from-to)1992-1998
Number of pages7
JournalJournal of neurophysiology
Volume81
Issue number4
DOIs
StatePublished - 1999

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