Novel florfenicol and chloramphenicol resistance gene discovered in alaskan soil by using functional metagenomics

Kevin S. Lang, Janet M. Anderson, Stefan Schwarz, Lynn Williamson, Jo Handelsman, Randall S. Singer

Research output: Contribution to journalArticlepeer-review

67 Scopus citations

Abstract

Functional metagenomics was used to search for florfenicol resistance genes in libraries of cloned DNA isolated from Alaskan soil. A gene that mediated reduced susceptibility to florfenicol was identified and designated pexA. The predicted PexA protein showed a structure similar to that of efflux pumps of the major facilitator superfamily.

Original languageEnglish (US)
Pages (from-to)5321-5326
Number of pages6
JournalApplied and environmental microbiology
Volume76
Issue number15
DOIs
StatePublished - Aug 2010

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