Novel Deazaflavin Analogues Potently Inhibited Tyrosyl DNA Phosphodiesterase 2 (TDP2) and Strongly Sensitized Cancer Cells toward Treatment with Topoisomerase II (TOP2) Poison Etoposide

Jayakanth Kankanala, Carlos J.A. Ribeiro, Evgeny Kiselev, Azhar Ravji, Jessica Williams, Jiashu Xie, Hideki Aihara, Yves Pommier, Zhengqiang Wang

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Biochemistry, Genetics and Molecular Biology