TY - JOUR
T1 - Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von willebrand factor
T2 - The charge (cohorts for heart and aging research in genome epidemiology) consortium
AU - Smith, Nicholas L.
AU - Chen, Ming Huei
AU - Dehghan, Abbas
AU - Strachan, David P.
AU - Basu, Saonli
AU - Soranzo, Nicole
AU - Hayward, Caroline
AU - Rudan, Igor
AU - Sabater-Lleal, Maria
AU - Bis, Joshua C.
AU - De Maat, Moniek P M
AU - Rumley, Ann
AU - Kong, Xiaoxiao
AU - Yang, Qiong
AU - Williams, Frances M K
AU - Vitart, Veronique
AU - Campbell, Harry
AU - Mälarstig, Anders
AU - Wiggins, Kerri L.
AU - Van Duijn, Cornelia M.
AU - McArdle, Wendy L.
AU - Pankow, James S.
AU - Johnson, Andrew D.
AU - Silveira, Angela
AU - McKnight, Barbara
AU - Uitterlinden, Andre G.
AU - Aleksic, Nena
AU - Meigs, James B.
AU - Peters, Annette
AU - Koenig, Wolfgang
AU - Cushman, Mary
AU - Kathiresan, Sekar
AU - Rotter, Jerome I.
AU - Bovill, Edwin G.
AU - Hofman, Albert
AU - Boerwinkle, Eric
AU - Tofler, Geoffrey H.
AU - Peden, John F.
AU - Psaty, Bruce M.
AU - Leebeek, Frank
AU - Folsom, Aaron R.
AU - Larson, Martin G.
AU - Spector, Timothy D.
AU - Wright, Alan F.
AU - Wilson, James F.
AU - Hamsten, Anders
AU - Lumley, Thomas
AU - Witteman, Jacqueline C M
AU - Tang, Weihong
AU - O'Donnell, Christopher J.
PY - 2010/3
Y1 - 2010/3
N2 - Background-Plasma levels of coagulation factors VII (FVII), VIII (FVIII), and von Willebrand factor (vWF) influence risk of hemorrhage and thrombosis. We conducted genome-wide association studies to identify new loci associated with plasma levels. Methods and Results-The setting of the study included 5 community-based studies for discovery comprising 23 608 European-ancestry participants: Atherosclerosis Risk In Communities Study, Cardiovascular Health Study, British 1958 Birth Cohort, Framingham Heart Study, and Rotterdam Study. All subjects had genome-wide single-nucleotide polymorphism (SNP) scans and at least 1 phenotype measured: FVII activity/antigen, FVIII activity, and vWF antigen. Each study used its genotype data to impute to HapMap SNPs and independently conducted association analyses of hemostasis measures using an additive genetic model. Study findings were combined by meta-analysis. Replication was conducted in 7604 participants not in the discovery cohort. For FVII, 305 SNPs exceeded the genome-wide significance threshold of 5.0×10 and comprised 5 loci on 5 chromosomes: 2p23 (smallest P value 6.2×10 -24), 4q25 (3.6×10-12), 11q12 (2.0×10 -10), 13q34 (9.0×10-259), and 20q11.2 (5.7×10-37). Loci were within or near genes, including 4 new candidate genes and F7 (13q34). For vWF, 400 SNPs exceeded the threshold and marked 8 loci on 6 chromosomes: 6q24 (1.2×10-10), 8p21 (1.3×10-16), 9q34 (<5.0×10-324), 12p13 (1.7×10-32), 12q23 (7.3×10-10), 12q24.3 (3.8×10-11), 14q32 (2.3×10-10), and 19p13.2 (1.3×10-9). All loci were within genes, including 6 new candidate genes, as well as ABO (9q34) and VWF (12p13). For FVIII, 5 loci were identified and overlapped vWF findings. Nine of the 10 new findings were replicated. CONCLUSIONS-: New genetic associations were discovered outside previously known biological pathways and may point to novel prevention and treatment targets of hemostasis disorders.
AB - Background-Plasma levels of coagulation factors VII (FVII), VIII (FVIII), and von Willebrand factor (vWF) influence risk of hemorrhage and thrombosis. We conducted genome-wide association studies to identify new loci associated with plasma levels. Methods and Results-The setting of the study included 5 community-based studies for discovery comprising 23 608 European-ancestry participants: Atherosclerosis Risk In Communities Study, Cardiovascular Health Study, British 1958 Birth Cohort, Framingham Heart Study, and Rotterdam Study. All subjects had genome-wide single-nucleotide polymorphism (SNP) scans and at least 1 phenotype measured: FVII activity/antigen, FVIII activity, and vWF antigen. Each study used its genotype data to impute to HapMap SNPs and independently conducted association analyses of hemostasis measures using an additive genetic model. Study findings were combined by meta-analysis. Replication was conducted in 7604 participants not in the discovery cohort. For FVII, 305 SNPs exceeded the genome-wide significance threshold of 5.0×10 and comprised 5 loci on 5 chromosomes: 2p23 (smallest P value 6.2×10 -24), 4q25 (3.6×10-12), 11q12 (2.0×10 -10), 13q34 (9.0×10-259), and 20q11.2 (5.7×10-37). Loci were within or near genes, including 4 new candidate genes and F7 (13q34). For vWF, 400 SNPs exceeded the threshold and marked 8 loci on 6 chromosomes: 6q24 (1.2×10-10), 8p21 (1.3×10-16), 9q34 (<5.0×10-324), 12p13 (1.7×10-32), 12q23 (7.3×10-10), 12q24.3 (3.8×10-11), 14q32 (2.3×10-10), and 19p13.2 (1.3×10-9). All loci were within genes, including 6 new candidate genes, as well as ABO (9q34) and VWF (12p13). For FVIII, 5 loci were identified and overlapped vWF findings. Nine of the 10 new findings were replicated. CONCLUSIONS-: New genetic associations were discovered outside previously known biological pathways and may point to novel prevention and treatment targets of hemostasis disorders.
KW - Epidemiology
KW - Factor VII
KW - Factor VIII
KW - Genetic variation
KW - Hemostasis
KW - Meta-analysis
KW - Thrombosis
KW - Von Willebrand factor
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U2 - 10.1161/CIRCULATIONAHA.109.869156
DO - 10.1161/CIRCULATIONAHA.109.869156
M3 - Article
C2 - 20231535
AN - SCOPUS:77950217693
SN - 0009-7322
VL - 121
SP - 1382
EP - 1392
JO - Circulation
JF - Circulation
IS - 12
ER -