Novel approaches to lipid based drug delivery

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Lipid based drug delivery is hardly new; however, it is experiencing a renaissance due to new applications, such as gene therapy, new methods of enhancing vesicle circulation in the bloodstream by steric stabilization, and novel self-assembly approaches to more complex structures. Interfacing electronic materials with lipids and proteins is also showing promise with possible applications toward combinatorial chemistry, biosensors, and protein separations. What appears necessary in all of these endeavors is a better appreciation of lipid phase behavior and its modifications due to the proteins, polymers and ions, and how these interactions can be best controlled to provide an optimal microstructure, combined with a careful understanding of the biomedical application to determine just what that optimal microstructure might be.

Original languageEnglish (US)
Pages (from-to)345-349
Number of pages5
JournalCurrent Opinion in Solid State and Materials Science
Volume2
Issue number3
DOIs
StatePublished - 1997

Bibliographical note

Funding Information:
Work from the author’s laboratory was supported by grants from the National Institutes of Health (GM47334), the National Science Foundation (NSF) (CTS-9305868 and CTS-9319447) and the MSERC (Materials Science and Engineering R&search Center) program of the NSF under grant DMR-9632716 and the Deootech Comoanv. I also thank MB Sankaram,J Weers, J Groves, J Wang, C ‘Safinyaa nd j Isiaelachvili for sharing preprints. My continuj~ thanks are due to my cufrent and former students and post-dots who have worked on these projects: Shivkumar Chiruvolu, Ed Naranjo, Scott Walker, Sarah Keller and Michael Kennedy.

Keywords

  • CL cardiolipin
  • PA phosphatidic acid
  • PEG polyethylene glycol
  • PS phosphatidylserine
  • RES reticulo-endothelial system

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