Notch signaling promotes growth and invasion in uveal melanoma

Keyphrases

• Active Form 20%
• Anchorage-independent 20%
• CBF1 20%
• Cell Invasion 20%
• Clonogenic Activity 20%
• Clonogenic Cells 20%
• Constitutively Active 20%
• Design Expressions 20%
• Extracellular Signal-regulated Kinase 1/2 20%
• Five Cells 20%
• Inhibitory Effect 20%
• Ligand-receptor Binding 20%
• Low Expression 20%
• Metastasis 20%
• MiRNA Target 20%
• MRK003 40%
• Notch Activation 20%
• Notch Activity 40%
• Notch Inhibition 20%
• Notch Ligands 20%
• Notch Pathway 20%
• Notch Receptors 20%
• Notch Signaling 100%
• Notch Targets 40%
• Notch1 20%
• Notch2 40%
• Ocular Malignancy 20%
• Pathway Activity 20%
• Pharmacologic 20%
• Phosphorylation State 20%
• Primary Tumor 20%
• Primary Uveal Melanoma 20%
• Promoting Growth 100%
• Receptor Targets 20%
• Short Hairpin RNA (shRNA) 20%
• Three-line 20%
• Tumor Growth 60%
• Tumor Invasion 40%
• Tumor Metastasis 20%
• Tumor Samples 20%
• Uveal Melanoma 100%
• Xenograft 20%
• γ-secretase Inhibitor 20%

Medicine and Dentistry

• Anchorage 14%
• Cancer 14%
• Cell Invasion 14%
• Cell Line 28%
• Metastatic Carcinoma 28%
• Mitogen Activated Protein Kinase 3 14%
• Notch 100%
• Notch Receptor 14%
• Notch Signaling 100%
• Primary Tumor 14%
• Secretase 14%
• Short Hairpin RNA 14%
• Tumor Invasion 28%
• Tumor Progression 42%
• Uveal Melanoma 100%
• Xenograft 14%

Pharmacology, Toxicology and Pharmaceutical Science

• Metastasis 16%
• Mitogen Activated Protein Kinase 3 16%
• Notch Receptor 16%
• Primary Tumor 16%
• Secretase 16%
• Short Hairpin RNA 16%
• Tumor Growth 50%
• Tumor Invasion 33%
• Uvea Melanoma 100%