TY - JOUR
T1 - Not simply misshapen red cells
T2 - Multimolecular and cellular events in sickle vaso-occlusion
AU - Vercellotti, Gregory M.
AU - Belcher, John D.
PY - 2014/4/1
Y1 - 2014/4/1
N2 - Thromboinflammatory diseases result from the interactions of vascular endothelial cells, inflammatory cells, and platelets with cellular adhesion molecules, plasma proteins, and lipids. Tipping the balance toward a prothrombotic, proinflammatory phenotype results from multicellular activation signals. In this issue of the JCI, Li et al. explore the regulation of heterotypic neutrophil-platelet contacts in response to TNF-α-induced venular inflammation with relevance to sickle cell disease (SCD).
AB - Thromboinflammatory diseases result from the interactions of vascular endothelial cells, inflammatory cells, and platelets with cellular adhesion molecules, plasma proteins, and lipids. Tipping the balance toward a prothrombotic, proinflammatory phenotype results from multicellular activation signals. In this issue of the JCI, Li et al. explore the regulation of heterotypic neutrophil-platelet contacts in response to TNF-α-induced venular inflammation with relevance to sickle cell disease (SCD).
UR - http://www.scopus.com/inward/record.url?scp=84897514444&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84897514444&partnerID=8YFLogxK
U2 - 10.1172/JCI75238
DO - 10.1172/JCI75238
M3 - Article
C2 - 24642460
AN - SCOPUS:84897514444
SN - 0021-9738
VL - 124
SP - 1462
EP - 1465
JO - Journal of Clinical Investigation
JF - Journal of Clinical Investigation
IS - 4
ER -
