Not simply misshapen red cells

Multimolecular and cellular events in sickle vaso-occlusion

Research output: Contribution to journalComment/debate

12 Citations (Scopus)

Abstract

Thromboinflammatory diseases result from the interactions of vascular endothelial cells, inflammatory cells, and platelets with cellular adhesion molecules, plasma proteins, and lipids. Tipping the balance toward a prothrombotic, proinflammatory phenotype results from multicellular activation signals. In this issue of the JCI, Li et al. explore the regulation of heterotypic neutrophil-platelet contacts in response to TNF-α-induced venular inflammation with relevance to sickle cell disease (SCD).

Original languageEnglish (US)
Pages (from-to)1462-1465
Number of pages4
JournalJournal of Clinical Investigation
Volume124
Issue number4
DOIs
StatePublished - Apr 1 2014

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Blood Platelets
Sickle Cell Anemia
Blood Proteins
Neutrophils
Endothelial Cells
Inflammation
Phenotype
Lipids

Cite this

Not simply misshapen red cells : Multimolecular and cellular events in sickle vaso-occlusion. / Vercellotti, Gregory M; Belcher, John D.

In: Journal of Clinical Investigation, Vol. 124, No. 4, 01.04.2014, p. 1462-1465.

Research output: Contribution to journalComment/debate

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