Normoalbuminuric diabetic kidney disease in the U.S. population

Amy K. Mottl, Keun Sang Kwon, Michael Mauer, Elizabeth J. Mayer-Davis, Susan L. Hogan, Abhijit V. Kshirsagar

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Background: This study sought to compare the prevalence and modifying factors of normoalbuminuric (NA) versus albuminuric (ALB) CKD in the U.S. diabetic and nondiabetic populations. Methods: NHANES 2001-2008 included 2798 diabetic and 15,743 nondiabetic participants. Age-specific prevalence of NA-CKD and ALB-CKD was calculated within each diabetes stratum and then stratified again according to gender, ethnicity, mean arterial pressure ≥ 105 mmHg and HbA1c ≥ 7%. Multivariate regression analyses were performed to determine odds ratios and 95% CI for NA-CKD. Results: Prevalence of NA-CKD rose with age, with an overall mean of 9.7% in diabetic and 4.3% in nondiabetic participants. NA-CKD was less prevalent in diabetic men, OR = 0.58 (95% CI: 0.39, 0.87). In comparison with whites, blacks and 'other' ethnic groups had an OR for NA-CKD of 0.44 (95% CI 0.29, 0.68) and 0.57 (95% CI: 0.34, 0.96), respectively. Poorly controlled blood pressure and glycemia resulted in a decreased OR for NA-CKD (OR = 0.25, 95% CI: 0.13, 0.50) and (0.48, 95% CI: 0.31, 0.74), respectively. Similar results were obtained for nondiabetic participants. Conclusions: NA-CKD is more common in people with diabetes, women, non-Hispanic whites, and in the setting of well controlled blood pressure and glycemia.

Original languageEnglish (US)
Pages (from-to)123-127
Number of pages5
JournalJournal of Diabetes and its Complications
Volume27
Issue number2
DOIs
StatePublished - Mar 1 2013

Fingerprint

Diabetic Nephropathies
Population
Blood Pressure
Nutrition Surveys
Ethnic Groups
Arterial Pressure
Multivariate Analysis
Odds Ratio
Regression Analysis

Keywords

  • Chronic Kidney Disease
  • Diabetes
  • Normoalbuminuria

Cite this

Mottl, A. K., Kwon, K. S., Mauer, M., Mayer-Davis, E. J., Hogan, S. L., & Kshirsagar, A. V. (2013). Normoalbuminuric diabetic kidney disease in the U.S. population. Journal of Diabetes and its Complications, 27(2), 123-127. https://doi.org/10.1016/j.jdiacomp.2012.09.010

Normoalbuminuric diabetic kidney disease in the U.S. population. / Mottl, Amy K.; Kwon, Keun Sang; Mauer, Michael; Mayer-Davis, Elizabeth J.; Hogan, Susan L.; Kshirsagar, Abhijit V.

In: Journal of Diabetes and its Complications, Vol. 27, No. 2, 01.03.2013, p. 123-127.

Research output: Contribution to journalArticle

Mottl, Amy K. ; Kwon, Keun Sang ; Mauer, Michael ; Mayer-Davis, Elizabeth J. ; Hogan, Susan L. ; Kshirsagar, Abhijit V. / Normoalbuminuric diabetic kidney disease in the U.S. population. In: Journal of Diabetes and its Complications. 2013 ; Vol. 27, No. 2. pp. 123-127.
@article{481ddbee1c9f49c4aa9ad90b4e5dc7f0,
title = "Normoalbuminuric diabetic kidney disease in the U.S. population",
abstract = "Background: This study sought to compare the prevalence and modifying factors of normoalbuminuric (NA) versus albuminuric (ALB) CKD in the U.S. diabetic and nondiabetic populations. Methods: NHANES 2001-2008 included 2798 diabetic and 15,743 nondiabetic participants. Age-specific prevalence of NA-CKD and ALB-CKD was calculated within each diabetes stratum and then stratified again according to gender, ethnicity, mean arterial pressure ≥ 105 mmHg and HbA1c ≥ 7{\%}. Multivariate regression analyses were performed to determine odds ratios and 95{\%} CI for NA-CKD. Results: Prevalence of NA-CKD rose with age, with an overall mean of 9.7{\%} in diabetic and 4.3{\%} in nondiabetic participants. NA-CKD was less prevalent in diabetic men, OR = 0.58 (95{\%} CI: 0.39, 0.87). In comparison with whites, blacks and 'other' ethnic groups had an OR for NA-CKD of 0.44 (95{\%} CI 0.29, 0.68) and 0.57 (95{\%} CI: 0.34, 0.96), respectively. Poorly controlled blood pressure and glycemia resulted in a decreased OR for NA-CKD (OR = 0.25, 95{\%} CI: 0.13, 0.50) and (0.48, 95{\%} CI: 0.31, 0.74), respectively. Similar results were obtained for nondiabetic participants. Conclusions: NA-CKD is more common in people with diabetes, women, non-Hispanic whites, and in the setting of well controlled blood pressure and glycemia.",
keywords = "Chronic Kidney Disease, Diabetes, Normoalbuminuria",
author = "Mottl, {Amy K.} and Kwon, {Keun Sang} and Michael Mauer and Mayer-Davis, {Elizabeth J.} and Hogan, {Susan L.} and Kshirsagar, {Abhijit V.}",
year = "2013",
month = "3",
day = "1",
doi = "10.1016/j.jdiacomp.2012.09.010",
language = "English (US)",
volume = "27",
pages = "123--127",
journal = "Journal of Diabetes and its Complications",
issn = "1056-8727",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Normoalbuminuric diabetic kidney disease in the U.S. population

AU - Mottl, Amy K.

AU - Kwon, Keun Sang

AU - Mauer, Michael

AU - Mayer-Davis, Elizabeth J.

AU - Hogan, Susan L.

AU - Kshirsagar, Abhijit V.

PY - 2013/3/1

Y1 - 2013/3/1

N2 - Background: This study sought to compare the prevalence and modifying factors of normoalbuminuric (NA) versus albuminuric (ALB) CKD in the U.S. diabetic and nondiabetic populations. Methods: NHANES 2001-2008 included 2798 diabetic and 15,743 nondiabetic participants. Age-specific prevalence of NA-CKD and ALB-CKD was calculated within each diabetes stratum and then stratified again according to gender, ethnicity, mean arterial pressure ≥ 105 mmHg and HbA1c ≥ 7%. Multivariate regression analyses were performed to determine odds ratios and 95% CI for NA-CKD. Results: Prevalence of NA-CKD rose with age, with an overall mean of 9.7% in diabetic and 4.3% in nondiabetic participants. NA-CKD was less prevalent in diabetic men, OR = 0.58 (95% CI: 0.39, 0.87). In comparison with whites, blacks and 'other' ethnic groups had an OR for NA-CKD of 0.44 (95% CI 0.29, 0.68) and 0.57 (95% CI: 0.34, 0.96), respectively. Poorly controlled blood pressure and glycemia resulted in a decreased OR for NA-CKD (OR = 0.25, 95% CI: 0.13, 0.50) and (0.48, 95% CI: 0.31, 0.74), respectively. Similar results were obtained for nondiabetic participants. Conclusions: NA-CKD is more common in people with diabetes, women, non-Hispanic whites, and in the setting of well controlled blood pressure and glycemia.

AB - Background: This study sought to compare the prevalence and modifying factors of normoalbuminuric (NA) versus albuminuric (ALB) CKD in the U.S. diabetic and nondiabetic populations. Methods: NHANES 2001-2008 included 2798 diabetic and 15,743 nondiabetic participants. Age-specific prevalence of NA-CKD and ALB-CKD was calculated within each diabetes stratum and then stratified again according to gender, ethnicity, mean arterial pressure ≥ 105 mmHg and HbA1c ≥ 7%. Multivariate regression analyses were performed to determine odds ratios and 95% CI for NA-CKD. Results: Prevalence of NA-CKD rose with age, with an overall mean of 9.7% in diabetic and 4.3% in nondiabetic participants. NA-CKD was less prevalent in diabetic men, OR = 0.58 (95% CI: 0.39, 0.87). In comparison with whites, blacks and 'other' ethnic groups had an OR for NA-CKD of 0.44 (95% CI 0.29, 0.68) and 0.57 (95% CI: 0.34, 0.96), respectively. Poorly controlled blood pressure and glycemia resulted in a decreased OR for NA-CKD (OR = 0.25, 95% CI: 0.13, 0.50) and (0.48, 95% CI: 0.31, 0.74), respectively. Similar results were obtained for nondiabetic participants. Conclusions: NA-CKD is more common in people with diabetes, women, non-Hispanic whites, and in the setting of well controlled blood pressure and glycemia.

KW - Chronic Kidney Disease

KW - Diabetes

KW - Normoalbuminuria

UR - http://www.scopus.com/inward/record.url?scp=84875222022&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875222022&partnerID=8YFLogxK

U2 - 10.1016/j.jdiacomp.2012.09.010

DO - 10.1016/j.jdiacomp.2012.09.010

M3 - Article

VL - 27

SP - 123

EP - 127

JO - Journal of Diabetes and its Complications

JF - Journal of Diabetes and its Complications

SN - 1056-8727

IS - 2

ER -