Normal formation and repair of γ-radiation-induced single and double strand DNA breaks in Down syndrome fibroblasts

Marie E. Steiner, William G. Woods

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Fibroblasts from patients with Down syndrome (Trisomy 21) were examined for repair capability of γ-radiation-induced single strand and double strand DNA breaks. Formation and repair of DNA breaks were determined by DNA alkaline and non-denaturing elution techniques. Down syndrome fibroblasts were found to repair single strand and double strand breaks as well as fibroblasts from normal controls.

Original languageEnglish (US)
Pages (from-to)515-523
Number of pages9
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume95
Issue number2-3
DOIs
StatePublished - Aug 1982

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Single-Stranded DNA Breaks
Double-Stranded DNA Breaks
Down Syndrome
Fibroblasts
Radiation
DNA Breaks
DNA

Cite this

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abstract = "Fibroblasts from patients with Down syndrome (Trisomy 21) were examined for repair capability of γ-radiation-induced single strand and double strand DNA breaks. Formation and repair of DNA breaks were determined by DNA alkaline and non-denaturing elution techniques. Down syndrome fibroblasts were found to repair single strand and double strand breaks as well as fibroblasts from normal controls.",
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