Fibroblasts from patients with Down syndrome (Trisomy 21) were examined for repair capability of γ-radiation-induced single strand and double strand DNA breaks. Formation and repair of DNA breaks were determined by DNA alkaline and non-denaturing elution techniques. Down syndrome fibroblasts were found to repair single strand and double strand breaks as well as fibroblasts from normal controls.
|Original language||English (US)|
|Number of pages||9|
|Journal||Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis|
|State||Published - Aug 1982|
Bibliographical noteFunding Information:
Supported in part by grants from the University of Minnesota Graduate School, American Cancer Society (ACS IN 13-S-59), Minnesota Medical Foundation, and March of Dimes Summer Science Research Program for Medical Students. Dr. Woods is a recipient of a Junior Faculty Clinical Fellowship from the American Cancer Society.