Abstract
Fibroblasts from patients with Down syndrome (Trisomy 21) were examined for repair capability of γ-radiation-induced single strand and double strand DNA breaks. Formation and repair of DNA breaks were determined by DNA alkaline and non-denaturing elution techniques. Down syndrome fibroblasts were found to repair single strand and double strand breaks as well as fibroblasts from normal controls.
Original language | English (US) |
---|---|
Pages (from-to) | 515-523 |
Number of pages | 9 |
Journal | Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis |
Volume | 95 |
Issue number | 2-3 |
DOIs | |
State | Published - Aug 1982 |
Bibliographical note
Funding Information:Supported in part by grants from the University of Minnesota Graduate School, American Cancer Society (ACS IN 13-S-59), Minnesota Medical Foundation, and March of Dimes Summer Science Research Program for Medical Students. Dr. Woods is a recipient of a Junior Faculty Clinical Fellowship from the American Cancer Society.