Normal cerebrospinal fluid levels of hypocretin-1 (orexin A) in patients with fibromyalgia syndrome

Oludare B. Taiwo; I. Jon Russell; Emmanuel Mignot; Ling Lin; Joel E. Michalek; Wanda Haynes; Yangming Xiao; Jamie M. Zeitzer; Alice A. Larson

doi:10.1016/j.sleep.2006.08.015

Normal cerebrospinal fluid levels of hypocretin-1 (orexin A) in patients with fibromyalgia syndrome

Oludare B. Taiwo, I. Jon Russell, Emmanuel Mignot, Ling Lin, Joel E. Michalek, Wanda Haynes, Yangming Xiao, Jamie M. Zeitzer, Alice A. Larson

Veterinary and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Background: The hypothalamic neuropeptide hypocretin (orexin) modulates sleep-wake, feeding and endocrine functions. Cerebrospinal fluid (CSF) hypocretin-1 (Hcrt-1) concentrations are low in patients with narcolepsy-cataplexy, a sleep disorder characterized by hypersomnolence and rapid eye movement (REM) sleep abnormalities. Methods: We determined CSF Hcrt-1 concentrations of patients with the fibromyalgia syndrome (FMS), a condition characterized by fatigue, insomnia and in some cases daytime hypersomnolence. Results: Basal CSF levels of Hcrt-1 in FMS did not differ from those in healthy normal controls. Conclusions: These findings suggest that abnormally low Hcrt-1 is not a likely cause of fatigue in FMS.

Original language	English (US)
Pages (from-to)	260-265
Number of pages	6
Journal	Sleep Medicine
Volume	8
Issue number	3
DOIs	https://doi.org/10.1016/j.sleep.2006.08.015
State	Published - Apr 2007

Bibliographical note

Funding Information:
This work was supported by NS23724 (EM) and the National Institutes of Health Grants DA 07234 (OBT) from the National Institute on Drug Abuse and NS39740 (AAL) funded by the National Institute of Neurological Disorders and Stroke and the National Institutes on Arthritis and Musculoskeletal and Skin Diseases. This work was also supported, in part, by a grant from Elan Pharmaceuticals and by a grant from the RGK Foundation of Austin, Texas.

Keywords

CSF
Clinical trial
Fibromyalgia
Hypocretin-1
Orexin-A
Sleep

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10.1016/j.sleep.2006.08.015

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@article{190568016d9d485e84c9175f0c13d3a1,

title = "Normal cerebrospinal fluid levels of hypocretin-1 (orexin A) in patients with fibromyalgia syndrome",

abstract = "Background: The hypothalamic neuropeptide hypocretin (orexin) modulates sleep-wake, feeding and endocrine functions. Cerebrospinal fluid (CSF) hypocretin-1 (Hcrt-1) concentrations are low in patients with narcolepsy-cataplexy, a sleep disorder characterized by hypersomnolence and rapid eye movement (REM) sleep abnormalities. Methods: We determined CSF Hcrt-1 concentrations of patients with the fibromyalgia syndrome (FMS), a condition characterized by fatigue, insomnia and in some cases daytime hypersomnolence. Results: Basal CSF levels of Hcrt-1 in FMS did not differ from those in healthy normal controls. Conclusions: These findings suggest that abnormally low Hcrt-1 is not a likely cause of fatigue in FMS.",

keywords = "CSF, Clinical trial, Fibromyalgia, Hypocretin-1, Orexin-A, Sleep",

author = "Taiwo, {Oludare B.} and Russell, {I. Jon} and Emmanuel Mignot and Ling Lin and Michalek, {Joel E.} and Wanda Haynes and Yangming Xiao and Zeitzer, {Jamie M.} and Larson, {Alice A.}",

note = "Funding Information: This work was supported by NS23724 (EM) and the National Institutes of Health Grants DA 07234 (OBT) from the National Institute on Drug Abuse and NS39740 (AAL) funded by the National Institute of Neurological Disorders and Stroke and the National Institutes on Arthritis and Musculoskeletal and Skin Diseases. This work was also supported, in part, by a grant from Elan Pharmaceuticals and by a grant from the RGK Foundation of Austin, Texas.",

year = "2007",

month = apr,

doi = "10.1016/j.sleep.2006.08.015",

language = "English (US)",

volume = "8",

pages = "260--265",

journal = "Sleep Medicine",

issn = "1389-9457",

publisher = "Elsevier",

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T1 - Normal cerebrospinal fluid levels of hypocretin-1 (orexin A) in patients with fibromyalgia syndrome

AU - Taiwo, Oludare B.

AU - Russell, I. Jon

AU - Mignot, Emmanuel

AU - Lin, Ling

AU - Michalek, Joel E.

AU - Haynes, Wanda

AU - Xiao, Yangming

AU - Zeitzer, Jamie M.

AU - Larson, Alice A.

N1 - Funding Information: This work was supported by NS23724 (EM) and the National Institutes of Health Grants DA 07234 (OBT) from the National Institute on Drug Abuse and NS39740 (AAL) funded by the National Institute of Neurological Disorders and Stroke and the National Institutes on Arthritis and Musculoskeletal and Skin Diseases. This work was also supported, in part, by a grant from Elan Pharmaceuticals and by a grant from the RGK Foundation of Austin, Texas.

PY - 2007/4

Y1 - 2007/4

N2 - Background: The hypothalamic neuropeptide hypocretin (orexin) modulates sleep-wake, feeding and endocrine functions. Cerebrospinal fluid (CSF) hypocretin-1 (Hcrt-1) concentrations are low in patients with narcolepsy-cataplexy, a sleep disorder characterized by hypersomnolence and rapid eye movement (REM) sleep abnormalities. Methods: We determined CSF Hcrt-1 concentrations of patients with the fibromyalgia syndrome (FMS), a condition characterized by fatigue, insomnia and in some cases daytime hypersomnolence. Results: Basal CSF levels of Hcrt-1 in FMS did not differ from those in healthy normal controls. Conclusions: These findings suggest that abnormally low Hcrt-1 is not a likely cause of fatigue in FMS.

AB - Background: The hypothalamic neuropeptide hypocretin (orexin) modulates sleep-wake, feeding and endocrine functions. Cerebrospinal fluid (CSF) hypocretin-1 (Hcrt-1) concentrations are low in patients with narcolepsy-cataplexy, a sleep disorder characterized by hypersomnolence and rapid eye movement (REM) sleep abnormalities. Methods: We determined CSF Hcrt-1 concentrations of patients with the fibromyalgia syndrome (FMS), a condition characterized by fatigue, insomnia and in some cases daytime hypersomnolence. Results: Basal CSF levels of Hcrt-1 in FMS did not differ from those in healthy normal controls. Conclusions: These findings suggest that abnormally low Hcrt-1 is not a likely cause of fatigue in FMS.

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KW - Orexin-A

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Normal cerebrospinal fluid levels of hypocretin-1 (orexin A) in patients with fibromyalgia syndrome

Abstract

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Keywords

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