Norepinephrine potentiates proinflammatory responses of human vaginal epithelial cells

Amanda J. Brosnahan, Lucy Vulchanova, Samantha R. Witta, Yuying Dai, Bryan J. Jones, David R. Brown

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

The vaginal epithelium provides a barrier to pathogens and recruits immune defenses through the secretion of cytokines and chemokines. Several studies have shown that mucosal sites are innervated by norepinephrine-containing nerve fibers. Here we report that norepinephrine potentiates the proinflammatory response of human vaginal epithelial cells to products produced by Staphylococcus aureus, a pathogen that causes menstrual toxic shock syndrome. The cells exhibit immunoreactivity for catecholamine synthesis enzymes and the norepinephrine transporter. Moreover, the cells secrete norepinephrine and dopamine at low concentrations. These results indicate that norepinephrine may serve as an autocrine modulator of proinflammatory responses in the vaginal epithelium.

Original languageEnglish (US)
Pages (from-to)8-16
Number of pages9
JournalJournal of Neuroimmunology
Volume259
Issue number1-2
DOIs
StatePublished - Jun 15 2013

Keywords

  • Catecholamine
  • Epithelium
  • Norepinephrine
  • Staphylococcus aureus
  • Superantigens
  • Toxic shock syndrome

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