TY - JOUR
T1 - Nonradiation risk factors for thyroid cancer in the US radiologic technologists study
AU - Meinhold, Cari L.
AU - Ron, Elaine
AU - Schonfeld, Sara J.
AU - Alexander, Bruce H.
AU - Freedman, D. Michal
AU - Linet, Martha S.
AU - Berrington De González, Amy
PY - 2010/1
Y1 - 2010/1
N2 - The incidence of thyroid cancer has been rapidly increasing in the United States, but few risk factors have been established. The authors prospectively examined the associations of self-reported medical history, anthropometric factors, and behavioral factors with thyroid cancer risk among 90,713 US radiologic technologists (69,506 women and 21,207 men) followed from 1983 through 2006. Incident thyroid cancers in 242 women and 40 men were reported. Elevated risks were observed for women with benign thyroid conditions (hazard ratio (HR) = 2.35, 95% confidence interval (CI): 1.73, 3.20), benign breast disease (HR) = 1.56, 95% CI: 1.08, 2.26), asthma (HR) = 1.68, 95% CI: 1.00, 2.83), and body mass index ≥35.0 versus 18.5-24.9 kg/m2 (HR) = 1.74, 95% CI: 1.03, 2.94; P-trend = 0.04). Current smoking was inversely associated with thyroid cancer risk (HR) = 0.54). No clear associations emerged for reproductive factors, other medical conditions, alcohol intake, or physical activity. Despite few thyroid cancers in men, men with benign thyroid conditions had a significantly increased risk of thyroid cancer (HR = 4.65, 95% CI: 1.62, 13.34), and results for other risk factors were similar to those for women. Consistent with prior studies, obesity and benign thyroid conditions increased and current smoking decreased the risk of thyroid cancer. The novel findings for benign breast disease and asthma warrant further investigation.
AB - The incidence of thyroid cancer has been rapidly increasing in the United States, but few risk factors have been established. The authors prospectively examined the associations of self-reported medical history, anthropometric factors, and behavioral factors with thyroid cancer risk among 90,713 US radiologic technologists (69,506 women and 21,207 men) followed from 1983 through 2006. Incident thyroid cancers in 242 women and 40 men were reported. Elevated risks were observed for women with benign thyroid conditions (hazard ratio (HR) = 2.35, 95% confidence interval (CI): 1.73, 3.20), benign breast disease (HR) = 1.56, 95% CI: 1.08, 2.26), asthma (HR) = 1.68, 95% CI: 1.00, 2.83), and body mass index ≥35.0 versus 18.5-24.9 kg/m2 (HR) = 1.74, 95% CI: 1.03, 2.94; P-trend = 0.04). Current smoking was inversely associated with thyroid cancer risk (HR) = 0.54). No clear associations emerged for reproductive factors, other medical conditions, alcohol intake, or physical activity. Despite few thyroid cancers in men, men with benign thyroid conditions had a significantly increased risk of thyroid cancer (HR = 4.65, 95% CI: 1.62, 13.34), and results for other risk factors were similar to those for women. Consistent with prior studies, obesity and benign thyroid conditions increased and current smoking decreased the risk of thyroid cancer. The novel findings for benign breast disease and asthma warrant further investigation.
KW - Body mass index
KW - Hormones
KW - Motor activity
KW - Prospective studies
KW - Reproduction
KW - Smoking
KW - Thyroid diseases
KW - Thyroid neoplasms
UR - http://www.scopus.com/inward/record.url?scp=73949142289&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=73949142289&partnerID=8YFLogxK
U2 - 10.1093/aje/kwp354
DO - 10.1093/aje/kwp354
M3 - Article
C2 - 19951937
AN - SCOPUS:73949142289
VL - 171
SP - 242
EP - 252
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
SN - 0002-9262
IS - 2
ER -