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Nonperfect synchronization of reaction center rehybridization in the transition state of the hydride transfer catalyzed by dihydrofolate reductase
Jingzhi Pu
, Shuhua Ma
, Mireia Garcia-Viloca
,
Jiali Gao
,
Donald G. Truhlar
, Amnon Kohen
Chemistry (Twin Cities)
Research output
:
Contribution to journal
›
Article
›
peer-review
55
Scopus citations
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Dive into the research topics of 'Nonperfect synchronization of reaction center rehybridization in the transition state of the hydride transfer catalyzed by dihydrofolate reductase'. Together they form a unique fingerprint.
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Keyphrases
Reaction Center
100%
Methylenetetrahydrofolate Reductase (MTHFR)
100%
Transition State
100%
Hydride Transfer
100%
Rehybridization
100%
Equilibrium Isotope Effect
33%
Tunneling
16%
Enzyme-catalyzed Reaction
16%
Product State
16%
Extent of Reaction
16%
Secondary Kinetic Isotope Effect
16%
Escherichia Coli Dihydrofolate Reductase
16%
Hybrid State
16%
Hydride Donor
16%
Catalyzed Reaction
16%
Chemistry
Transition State
100%
Dihydrofolates
100%
Donor
33%
Isotope Effect
33%
Enzymatic Reaction
16%
Kinetic Isotope Effect
16%