TY - JOUR
T1 - Nonlinear relation of the circadian blood pressure amplitude to cardiovascular disease risk
AU - Cornelissen-Guillaume, Germaine G
AU - Otsuka, K.
AU - Chen, CH H.
AU - Kumagai, Y.
AU - Watanabe, Y.
AU - Halberg, F.
AU - Siegelova, J.
AU - Dusek, J.
PY - 2000
Y1 - 2000
N2 - Data from two independent studies are reanalyzed to determine how the MESOR and the circadian amplitude (A) of blood pressure (BP) as well as the 24-hour standard deviation (SD) of heart rate (HR) relate to vascular disease risk. In one prospective study, risk is quantified by the actual number of events that occurred within 6 years. In the other retrospective study, the left ventricular mass index (LVMI) was used as a surrogate outcome measure available for all subjects. The BP MESOR is found to be linearly related to risk. By contrast, the circadian BP-A and the 24-hour SD of HR show a nonlinear relation with risk, which is elevated only after a threshold value for BP-A or HR-SD is exceeded. For the diagnosis of a deviation in BP and HR, the recommendation to monitor for 7 days at the outset seems as reliable an assessment as practical, but it may not be sufficient, and the patient must be advised that further monitoring may be needed.
AB - Data from two independent studies are reanalyzed to determine how the MESOR and the circadian amplitude (A) of blood pressure (BP) as well as the 24-hour standard deviation (SD) of heart rate (HR) relate to vascular disease risk. In one prospective study, risk is quantified by the actual number of events that occurred within 6 years. In the other retrospective study, the left ventricular mass index (LVMI) was used as a surrogate outcome measure available for all subjects. The BP MESOR is found to be linearly related to risk. By contrast, the circadian BP-A and the 24-hour SD of HR show a nonlinear relation with risk, which is elevated only after a threshold value for BP-A or HR-SD is exceeded. For the diagnosis of a deviation in BP and HR, the recommendation to monitor for 7 days at the outset seems as reliable an assessment as practical, but it may not be sufficient, and the patient must be advised that further monitoring may be needed.
KW - Cardiovascular disease risk
KW - Circadian blood pressure amplitude
KW - Essential hypertension
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M3 - Article
AN - SCOPUS:0033753889
SN - 1211-3395
VL - 73
SP - 87
EP - 96
JO - Scripta Medica Facultatis Medicae Universitatis Brunensis Masarykianae
JF - Scripta Medica Facultatis Medicae Universitatis Brunensis Masarykianae
IS - 2
ER -
