Nonlinear imaging methods for characterization of HIFU-induced lesions

Hui Yao, Pornchai Phukpattaranont, Emad S. Ebbini

Research output: Contribution to journalConference articlepeer-review

1 Scopus citations


Nonlinear ultrasonic imaging methods (like pulse inversion1 and quadratic imaging based second-order Volterra filter8) are used in visualization of lesion formation in freshly excised tissue. Both of these methods are more sensitive to nonlinear echoes (e.g., due to micro-bubbles) than standard B-mode imaging. While all three methods typically show increased echogenicity at the lesion location, the nonlinear methods exhibit more localized echo enhancement than B-mode imaging. Therefore, nonlinear methods are potentially better suited to lesion mapping for purposes of image guidance. Quadratic images have the added advantage of a significant increase in image dynamic range and noise reduction (a major limitation of pulse inversion imaging). The results shown in this report continue to support the hypothesis that micro-bubbles play an important role of lesion formation. In this paper, we present imaging results before and after volumetric lesion formation in ex vivo tissue. The results illustrate the advantage of nonlinear imaging methods compared to conventional B-scan imaging in terms of accurate mapping of lesion size and location.

Original languageEnglish (US)
Pages (from-to)183-191
Number of pages9
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - 2003
EventThermal treatment of Tissue:Energy Delivery and Assessment II - San Jose,CA, United States
Duration: Jan 26 2003Jan 27 2003


  • Autoregressive modelling
  • Image guidance
  • Noninvasive surgery
  • Phased arrays
  • Treatment monitoring
  • Ultrasonic imaging


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