Nonlinear dynamics of periodically paced cardiac tissue

Elena G. Tolkacheva, Xiaopeng Zhao

Research output: Contribution to journalReview article

10 Scopus citations


This manuscript reviews various experimental methods and mathematical approaches for nonlinear dynamics of paced cardiac tissue. A particular focus is on cardiac alternans. Several mapping models are introduced to predict alternans at the cellular level. Experimental observations and modeling approaches are introduced to understand mechanisms of alternans formation in extended heart tissue. In addition, potential bifurcation mechanisms of alternans and the underlying interplay between calcium and voltage dynamics are discussed.

Original languageEnglish (US)
Pages (from-to)347-363
Number of pages17
JournalNonlinear Dynamics
Issue number3
StatePublished - May 1 2012



  • Action potential duration
  • Alternans
  • Bifurcations
  • Restitution

Cite this