Nonlinear chiral rheology of phospholipid monolayers

Kyuhan Kim, Siyoung Q. Choi, Joseph A. Zasadzinski, Todd M. Squires

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Microbutton rheometry reveals that the chiral morphology of dipalmitoylphosphatidylcholine (DPPC) monolayers imparts a chiral nonlinear rheological response. The nonlinear elastic modulus and yield stress of DPPC monolayers are greater when sheared clockwise (C), against the natural winding direction of DPPC domains, than counter-clockwise (CC). Under strong CC shear strains, domains deform plastically; by contrast, domains appear to fracture under strong C shearing. After CC shearing, extended LC domains develop regular patterns of new invaginations as they recoil, which we hypothesize reflect the nucleation and growth of new defect lines across which the tilt direction undergoes a step change in orientation. The regular spacing of these twist-gradient defects is likely set by a competition between the molecular chirality and the correlation length of the DPPC lattice. The macroscopic mechanical consequences of DPPC's underlying molecular chirality are remarkable, given the single-component, non-cross-linked nature of the monolayers they form.

Original languageEnglish (US)
Pages (from-to)2476-2483
Number of pages8
JournalSoft Matter
Volume14
Issue number13
DOIs
StatePublished - 2018

Bibliographical note

Funding Information:
The authors acknowledge support from National Institutes of Health Grants HL 51177, HL 135065 and NSF Grant CBET 170378 and the Basic Science Research Program through the National Research Foundation of Korea, NRF-2015R1C1A1A01054180, (KHK, SQC).

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