Noninvasive quantification of ascorbate and glutathione concentration in the elderly human brain

Uzay E. Emir, Susan Raatz, Susan Mcpherson, James S. Hodges, Carolyn Torkelson, Pierre Tawfik, Tonya White, Melissa Terpstra

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

In this study, ascorbate (Asc) and glutathione (GSH) concentrations were quantified noninvasively using double-edited 1H MRS at 4 T in the occipital cortex of healthy young [age (mean±standard deviation)=20.4±1.4 years] and elderly (age=76.6±6.1 years) human subjects. Elderly subjects had a lower GSH concentration than younger subjects (p<0.05). The Asc concentration was not significantly associated with age. Furthermore, the lactate (Lac) concentration was higher in elderly than young subjects. Lower GSH and higher Lac concentrations are indications of defective protection against oxidative damage and impaired mitochondrial respiration. The extent to which the observed concentration differences could be associated with physiological differences and methodological artifacts is discussed. In conclusion, GSH and Asc concentrations were compared noninvasively for the first time in young vs elderly subjects.

Original languageEnglish (US)
Pages (from-to)888-894
Number of pages7
JournalNMR in biomedicine
Volume24
Issue number7
DOIs
StatePublished - Aug 2011

Keywords

  • Aging
  • Ascorbate
  • Brain
  • Glutathione
  • Human
  • Lactate
  • MEGA-PRESS
  • MRS

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