A recently developed heart-model-based localization approach is experimentally evaluated in noninvasively localizing the site of origin of cardiac activation in a patient with a pacemaker. The heart-torso model of the patient was constructed from the contrast ultrafast computed tomography images. The site of initial paced activation in the patient was quantitatively localized and compared with the tip position of the pacemaker lead. The localization error of the inverse estimation was found to be 5.2 mm with respect to the true lead tip position. The promising result of this pilot experimental study suggests the feasibility of localizing the site of origin of cardiac activation in an experimental setting. The heart-model-based localization approach may become an alternative tool in localizing the site of origin of cardiac activation.
Bibliographical noteFunding Information:
Manuscript received April 12, 2002; revised February 14, 2003. This work was supported in part by American Heart Association under Grant 0140132N, in part by the National Science Foundation (NSF) under Grant BES-0201939 and NSF CAREER Award BES-9875344, and in part by the National Institutes of Health (NIH) under Grant R01EB00178. Asterisk indicates corresponding author.
- Body surface potential map
- Cardiac activation
- Electrocardiographic inverse problem
- Pace mapping