Nongenomic actions of estrogens and xenoestrogens affecting endocrine cancer cells

Cheryl S. Watson; Dragoslava Zivadinovic; Yow Jiun Jeng; Rebecca A. Alyea; Terumi Midoro-Horiuti; Randall Goldblum; Anannya Banga

doi:10.1007/978-1-4614-1764-4_8

Nongenomic actions of estrogens and xenoestrogens affecting endocrine cancer cells

Cheryl S. Watson, Dragoslava Zivadinovic, Yow Jiun Jeng, Rebecca A. Alyea, Terumi Midoro-Horiuti, Randall Goldblum, Anannya Banga

Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Estrogens act via multiple membrane-associated receptors (α, β, and GPR30) to mediate diverse rapid signaling cascades affecting functional endpoints in both normal and cancer cells. The mitogen-activated protein kinases are a summative signaling node that integrates upstream signaling cascades into responses for major functional cellular outcomes such as proliferation, migration, differentiation, and death. These responses are complex; they oscillate with time, as well as fluctuate up and down with increasing ligand concentration (hormesis). Nonphysiologic estrogenic compounds also use these receptors and signaling systems, but do so imperfectly, causing disruptions to both the phasing and dose-responsiveness of physiologic estrogens. Disruptions to the signaling of different physiologic estrogens could cause life stage-specific tissue malfunctions or cancer vulnerabilities.

Original language	English (US)
Title of host publication	Advances in Rapid Sex-Steroid Action
Subtitle of host publication	New Challenges and New Chances in Breast and Prostate Cancers
Publisher	Springer New York
Pages	129-142
Number of pages	14
Volume	9781461417644
ISBN (Electronic)	9781461417644
ISBN (Print)	1461417635, 9781461417637
DOIs	https://doi.org/10.1007/978-1-4614-1764-4_8
State	Published - Aug 1 2012

Bibliographical note

Publisher Copyright:
© 2012 Springer Science+Business Media, LLC. All rights reserved.

Keywords

Breast cancer
Estrogens
Immune system
Ligand mixtures
Membrane estrogen receptors
Neurons
Nongenomic
Nonmonotonic
Pituitary
Xenoestrogens

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-1-4614-1764-4_8

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Watson, C. S., Zivadinovic, D., Jeng, Y. J., Alyea, R. A., Midoro-Horiuti, T., Goldblum, R., & Banga, A. (2012). Nongenomic actions of estrogens and xenoestrogens affecting endocrine cancer cells. In Advances in Rapid Sex-Steroid Action: New Challenges and New Chances in Breast and Prostate Cancers (Vol. 9781461417644, pp. 129-142). Springer New York. https://doi.org/10.1007/978-1-4614-1764-4_8

Nongenomic actions of estrogens and xenoestrogens affecting endocrine cancer cells. / Watson, Cheryl S.; Zivadinovic, Dragoslava; Jeng, Yow Jiun et al.
Advances in Rapid Sex-Steroid Action: New Challenges and New Chances in Breast and Prostate Cancers. Vol. 9781461417644 Springer New York, 2012. p. 129-142.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Watson, CS, Zivadinovic, D, Jeng, YJ, Alyea, RA, Midoro-Horiuti, T, Goldblum, R & Banga, A 2012, Nongenomic actions of estrogens and xenoestrogens affecting endocrine cancer cells. in Advances in Rapid Sex-Steroid Action: New Challenges and New Chances in Breast and Prostate Cancers. vol. 9781461417644, Springer New York, pp. 129-142. https://doi.org/10.1007/978-1-4614-1764-4_8

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AB - Estrogens act via multiple membrane-associated receptors (α, β, and GPR30) to mediate diverse rapid signaling cascades affecting functional endpoints in both normal and cancer cells. The mitogen-activated protein kinases are a summative signaling node that integrates upstream signaling cascades into responses for major functional cellular outcomes such as proliferation, migration, differentiation, and death. These responses are complex; they oscillate with time, as well as fluctuate up and down with increasing ligand concentration (hormesis). Nonphysiologic estrogenic compounds also use these receptors and signaling systems, but do so imperfectly, causing disruptions to both the phasing and dose-responsiveness of physiologic estrogens. Disruptions to the signaling of different physiologic estrogens could cause life stage-specific tissue malfunctions or cancer vulnerabilities.

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Nongenomic actions of estrogens and xenoestrogens affecting endocrine cancer cells

Abstract

Bibliographical note

Keywords

UN SDGs

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