Noncovalent dimerization of ubiquitin

Zhu Liu; Wei Ping Zhang; Qiong Xing; Xuefeng Ren; Maili Liu; Chun Tang

doi:10.1002/anie.201106190

Noncovalent dimerization of ubiquitin

Zhu Liu, Wei Ping Zhang, Qiong Xing, Xuefeng Ren, Maili Liu, Chun Tang

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Abstract

Another kind of dynamics: Ubiquitin noncovalently dimerizes with a dissociation constant of approximately 5mM. The two subunits adopt an array of relative orientations, utilizing an interface also for binding to other proteins (see picture). Quaternary fluctuation among members of the dimer ensemble constitutes a different kind of dynamics that complements the tertiary dynamics of each ubiquitin subunit.

Original language	English (US)
Pages (from-to)	469-472
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	2
DOIs	https://doi.org/10.1002/anie.201106190
State	Published - Jan 9 2012
Externally published	Yes

Keywords

NMRspectroscopy
dimerization
paramagnetic relaxation enhancement
protein-protein interactions
ubiquitin

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10.1002/anie.201106190

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abstract = "Another kind of dynamics: Ubiquitin noncovalently dimerizes with a dissociation constant of approximately 5mM. The two subunits adopt an array of relative orientations, utilizing an interface also for binding to other proteins (see picture). Quaternary fluctuation among members of the dimer ensemble constitutes a different kind of dynamics that complements the tertiary dynamics of each ubiquitin subunit.",

keywords = "NMRspectroscopy, dimerization, paramagnetic relaxation enhancement, protein-protein interactions, ubiquitin",

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AU - Liu, Zhu

AU - Zhang, Wei Ping

AU - Xing, Qiong

AU - Ren, Xuefeng

AU - Liu, Maili

AU - Tang, Chun

PY - 2012/1/9

Y1 - 2012/1/9

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KW - NMRspectroscopy

KW - dimerization

KW - paramagnetic relaxation enhancement

KW - protein-protein interactions

KW - ubiquitin

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JF - Angewandte Chemie - International Edition

IS - 2

ER -

Noncovalent dimerization of ubiquitin

Abstract

Keywords

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