Non-viral-related pathologic findings in liver needle biopsy specimens from patients with chronic viral hepatitis

Vidhya Nair, Sandra Elisabeth Fischer, Oyedele Adewale Adeyi

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Liver biopsy is a vital part of chronic viral hepatitis management. Pathologists should view these biopsies as screening tools for other liver diseases. We describe our experience in a 6-year period and discuss the pathologist's role. Liver biopsies of 1,842 patients with hepatitis B or C, for the 2001-2007 period at the University Health Network, Toronto, Canada, were reviewed; 410 other diagnoses were documented in 377 patients (20.5%; mean age, 25.4 years; range, 15-80 years). These diagnoses included 58 hepatocellular carcinomas and 16 dysplastic nodules, which are recognized complications of chronic viral hepatitis. The remaining findings included the following: steatosis/ steatohepatitis, 251; hemosiderosis, 62; granulomatous disease, 7; drug-induced hepatitis, 4; primary biliary cirrhosis, 3; Wilson disease, 2; metastases, 2; and cholangiocarcinoma, atypical lymphoid proliferation, α1-antitrypsin deficiency, cystic fibrosis, and schistosomiasis, 1 each. Liver biopsies in patients with viral hepatitis revealed other processes with the potential to modify disease progression and/or the management strategy in 20.5% of patients.

Original languageEnglish (US)
Pages (from-to)127-132
Number of pages6
JournalAmerican journal of clinical pathology
Issue number1
StatePublished - Jan 2010
Externally publishedYes


  • Chronic viral hepatitis
  • Liver biopsy
  • Nonviral

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