Non-syndromic and syndromic keratocystic odontogenic tumors: Systematic review and meta-analysis of recurrences

Georgios N. Antonoglou, George K. Sándor, Vasiliki P. Koidou, Spyridon N. Papageorgiou

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40 Scopus citations


Background Keratocystic odontogenic tumors (KCOTs) are locally aggressive benign tumors which occur in the bones of both jaws with a high recurrence rate. The aim of the present study was to define and evaluate the post-treatment recurrence of KCOT lesions in non-syndromic and syndromic patients. Methods A systematic review of the literature and meta-analysis was conducted according to the PRISMA statement. Seven electronic databases were searched from their start up to August 2013 for clinical studies on human patients without limitation to year, language or publication status.

Results A total of five case series studies with 323 treated KCOT lesions were included in the quantitative synthesis. The recurrence rate of KCOTs for three treatment forms ranged from 7% to 28%. Comparisons among the various treatments suggest that resection or marsupialization might be associated with fewer recurrences. However, high risk of bias and effect imprecision preclude the making of clinical recommendation. Existing evidence regarding nevoid basal cell carcinoma patients was likewise scarce.

Conclusions The absence of studies with low risk of bias precludes the making of safe recommendations about the optimal management of KCOTs.

Original languageEnglish (US)
Pages (from-to)e364-e371
JournalJournal of Cranio-Maxillofacial Surgery
Issue number7
StatePublished - Oct 1 2014

Bibliographical note

Funding Information:
This study was funded by an EVO grant from the Oulu University Hospital Pohjois-Pohjanmaan Sairaanhoitopiiri .

Publisher Copyright:
© 2014 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.


  • Basal cell nevus syndrome
  • Gorlin-Goltz syndrome
  • KCOT
  • Keratocystic odontogenic tumor
  • Recurrence


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