Non respiratory metabolic function and morphology of lung following exposure to polybrominated biphenyls in rats

K. M. McCormack, R. A. Roth, K. B. Wallace, L. M. Ross, J. B. Hook1

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Abstract

Exposure to polybrominated biphenyls (PBBs) resulted in increased activity of microsomal aryihydrocarbon hydroxylase and ethoxyresorufin-O-deethylase in rat lung. Clearance of 5-hydroxytryptamine (S-HT) and angiotensin/by perfused lungs was decreased by PBBs. However, PBBs had no effect on the activity of epoxide hydrolase, monoamine oxidase, or angiotensin-converting enzyme in lung. The only histopathologic change detected in lungs from PBB-treated rats was an increase in alveolar type //cell lamellar bodies. Selective accumulation of certain PBB congeners by lung was not observed ¡n this investigation

Original languageEnglish (US)
Pages (from-to)27-39
Number of pages13
JournalJournal of Toxicology and Environmental Health
Volume9
Issue number1
DOIs
StatePublished - Jan 1982

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Polybrominated Biphenyls
Rats
Hydrolases
Lung
Enzymes
Alveolar Epithelial Cells
Epoxide Hydrolases
Cytochrome P-450 CYP1A1
Monoamine Oxidase
Angiotensins
Peptidyl-Dipeptidase A
Mixed Function Oxygenases
Serotonin

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Non respiratory metabolic function and morphology of lung following exposure to polybrominated biphenyls in rats. / McCormack, K. M.; Roth, R. A.; Wallace, K. B.; Ross, L. M.; Hook1, J. B.

In: Journal of Toxicology and Environmental Health, Vol. 9, No. 1, 01.1982, p. 27-39.

Research output: Contribution to journalArticle

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