Non respiratory metabolic function and morphology of lung following exposure to polybrominated biphenyls in rats

K. M. McCormack, R. A. Roth, K. B. Wallace, L. M. Ross, J. B. Hook1

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Abstract

Exposure to polybrominated biphenyls (PBBs) resulted in increased activity of microsomal aryihydrocarbon hydroxylase and ethoxyresorufin-O-deethylase in rat lung. Clearance of 5-hydroxytryptamine (S-HT) and angiotensin/by perfused lungs was decreased by PBBs. However, PBBs had no effect on the activity of epoxide hydrolase, monoamine oxidase, or angiotensin-converting enzyme in lung. The only histopathologic change detected in lungs from PBB-treated rats was an increase in alveolar type //cell lamellar bodies. Selective accumulation of certain PBB congeners by lung was not observed ¡n this investigation

Original languageEnglish (US)
Pages (from-to)27-39
Number of pages13
JournalJournal of Toxicology and Environmental Health
Volume9
Issue number1
DOIs
StatePublished - Jan 1982

Bibliographical note

Funding Information:
We wish to express our appreciation to Dr. K. K. Baker (Center for Electron Optics) for assistance with histopathology, Dr. W. E. Braselton, Jr. (Dept. of Pharmacology and Toxicology) for assistance with PBB quantification, D. M. Wilson, L. F. Lepperand L. Dotzlaf for technical assistance, and D. K. Hummel for help in manuscript preparation. This investigation was supported in part by National Institute of Environmental Health Sciences grants ES00560 and ESO1861 and by a grant from the Michigan Department of Agriculture. Agriculture Experiment Station journal article 9949. Requests for reprints should be sent to J. B. Hook, Center for Environmental Toxicology, Michigan State University, East Lansing, Michigan 48824.

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