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Non-markovian transport of long DNA in microfabricated arrays

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We present a detailed theoretical study of the mechanism of separation of long DNA through micro fabricated or self-assembled arrays of posts, focusing upon the non- Markovian nature of the transport. The resulting predictions for the average DNA velocity, dispersivity. band broadening, and separation resolution compare favourably with our recent experimental work on large-scale separations of DNA mixtures and detailed single- molecule observations in self-assembled magnetic arrays. The generic theory is valid for any post array.

Original languageEnglish (US)
Title of host publicationMicro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference
Subtitle of host publication9th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherTransducer Research Foundation
Pages1009-1011
Number of pages3
ISBN (Print)0974361119, 9780974361116
StatePublished - 2005
Event9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005 - Boston, MA, United States
Duration: Oct 9 2005 → Oct 13 2005

Publication series

NameMicro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Volume1

Other

Other9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005
Country/TerritoryUnited States
CityBoston, MA
Period10/9/05 → 10/13/05

Keywords

  • DNA
  • Diffusion
  • Electrophoresis
  • Modelling

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