Non-markovian transport of long DNA in microfabricated arrays

N. Minc, J. L. Viovy, K. D. Dorfman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We present a detailed theoretical study of the mechanism of separation of long DNA through micro fabricated or self-assembled arrays of posts, focusing upon the non- Markovian nature of the transport. The resulting predictions for the average DNA velocity, dispersivity. band broadening, and separation resolution compare favourably with our recent experimental work on large-scale separations of DNA mixtures and detailed single- molecule observations in self-assembled magnetic arrays. The generic theory is valid for any post array.

Original languageEnglish (US)
Title of host publicationMicro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference
Subtitle of host publication9th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherTransducer Research Foundation
Pages1009-1011
Number of pages3
ISBN (Print)0974361119, 9780974361116
StatePublished - Jan 1 2005
Event9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005 - Boston, MA, United States
Duration: Oct 9 2005Oct 13 2005

Publication series

NameMicro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Volume1

Other

Other9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005
CountryUnited States
CityBoston, MA
Period10/9/0510/13/05

Keywords

  • DNA
  • Diffusion
  • Electrophoresis
  • Modelling

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