Non-linear model reduction for metabolic networks with multiple time scales

Ziomara P. Gerdtzen; Prodromos Daoutidis; Wei-Shou Hu

doi:10.1109/.2005.1467069

Non-linear model reduction for metabolic networks with multiple time scales

Ziomara P. Gerdtzen, Prodromos Daoutidis, Wei-Shou Hu

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We present a method for obtaining non-stiff non-linear reduced-order models for metabolic networks, which exhibit dynamics in multiple time scales. The method is based on the successive application of singular perturbation arguments, starting from the fastest time scale and proceeding to the slowest one. The method is successfully applied to a detailed model of central carbon metabolism in human erythrocytes.

Original language	English (US)
Title of host publication	Proceedings of the 20th IEEE International Symposium on Intelligent Control, ISIC '05 and the 13th Mediterranean Conference on Control and Automation, MED '05
Pages	519-524
Number of pages	6
DOIs	https://doi.org/10.1109/.2005.1467069
State	Published - 2005
Event	20th IEEE International Symposium on Intelligent Control, ISIC '05 and the13th Mediterranean Conference on Control and Automation, MED '05 - Limassol, Cyprus Duration: Jun 27 2005 → Jun 29 2005

Publication series

Name	Proceedings of the 20th IEEE International Symposium on Intelligent Control, ISIC '05 and the 13th Mediterranean Conference on Control and Automation, MED '05
Volume	2005

Other

Other	20th IEEE International Symposium on Intelligent Control, ISIC '05 and the13th Mediterranean Conference on Control and Automation, MED '05
Country/Territory	Cyprus
City	Limassol
Period	6/27/05 → 6/29/05

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10.1109/.2005.1467069

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Gerdtzen, Z. P., Daoutidis, P., & Hu, W.-S. (2005). Non-linear model reduction for metabolic networks with multiple time scales. In Proceedings of the 20th IEEE International Symposium on Intelligent Control, ISIC '05 and the 13th Mediterranean Conference on Control and Automation, MED '05 (pp. 519-524). Article 1467069 (Proceedings of the 20th IEEE International Symposium on Intelligent Control, ISIC '05 and the 13th Mediterranean Conference on Control and Automation, MED '05; Vol. 2005). https://doi.org/10.1109/.2005.1467069

Non-linear model reduction for metabolic networks with multiple time scales. / Gerdtzen, Ziomara P.; Daoutidis, Prodromos ; Hu, Wei-Shou.
Proceedings of the 20th IEEE International Symposium on Intelligent Control, ISIC '05 and the 13th Mediterranean Conference on Control and Automation, MED '05. 2005. p. 519-524 1467069 (Proceedings of the 20th IEEE International Symposium on Intelligent Control, ISIC '05 and the 13th Mediterranean Conference on Control and Automation, MED '05; Vol. 2005).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Gerdtzen, ZP, Daoutidis, P & Hu, W-S 2005, Non-linear model reduction for metabolic networks with multiple time scales. in Proceedings of the 20th IEEE International Symposium on Intelligent Control, ISIC '05 and the 13th Mediterranean Conference on Control and Automation, MED '05., 1467069, Proceedings of the 20th IEEE International Symposium on Intelligent Control, ISIC '05 and the 13th Mediterranean Conference on Control and Automation, MED '05, vol. 2005, pp. 519-524, 20th IEEE International Symposium on Intelligent Control, ISIC '05 and the13th Mediterranean Conference on Control and Automation, MED '05, Limassol, Cyprus, 6/27/05. https://doi.org/10.1109/.2005.1467069

Gerdtzen ZP, Daoutidis P , Hu WS. Non-linear model reduction for metabolic networks with multiple time scales. In Proceedings of the 20th IEEE International Symposium on Intelligent Control, ISIC '05 and the 13th Mediterranean Conference on Control and Automation, MED '05. 2005. p. 519-524. 1467069. (Proceedings of the 20th IEEE International Symposium on Intelligent Control, ISIC '05 and the 13th Mediterranean Conference on Control and Automation, MED '05). doi: 10.1109/.2005.1467069

Gerdtzen, Ziomara P. ; Daoutidis, Prodromos ; Hu, Wei-Shou. / Non-linear model reduction for metabolic networks with multiple time scales. Proceedings of the 20th IEEE International Symposium on Intelligent Control, ISIC '05 and the 13th Mediterranean Conference on Control and Automation, MED '05. 2005. pp. 519-524 (Proceedings of the 20th IEEE International Symposium on Intelligent Control, ISIC '05 and the 13th Mediterranean Conference on Control and Automation, MED '05).

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Non-linear model reduction for metabolic networks with multiple time scales

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