Non-linear model reduction for energy metabolism in saccharomyces cerevisiae

Ziomara P. Gerdtzen, Prodromos Daoutidis, Wei Shou Hu

Research output: Contribution to journalConference articlepeer-review

2 Scopus citations

Abstract

A nonlinear model reduction method based on time scale analysis was applied to a detailed mechanistic model of the glucose catabolic pathway in S. cerevisiae. The method allows to identify quasi steady state constraints of complete conversion and reaction equilibrium corresponding to the fast reactions of the pathway, and to derive a reduced-order nonlinear model of the pathway dynamics for the time scale of interest, in terms of suitable linear combinations of the species concentrations. Numerical simulations were performed to validate the utilization of the reduced model in the description of the metabolic network.

Original languageEnglish (US)
Pages (from-to)2867-2872
Number of pages6
JournalProceedings of the American Control Conference
Volume4
DOIs
StatePublished - 2002
Event2002 American Control Conference - Anchorage, AK, United States
Duration: May 8 2002May 10 2002

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