TY - JOUR
T1 - Non-linear model reduction for energy metabolism in saccharomyces cerevisiae
AU - Gerdtzen, Ziomara P.
AU - Daoutidis, Prodromos
AU - Hu, Wei Shou
PY - 2002
Y1 - 2002
N2 - A nonlinear model reduction method based on time scale analysis was applied to a detailed mechanistic model of the glucose catabolic pathway in S. cerevisiae. The method allows to identify quasi steady state constraints of complete conversion and reaction equilibrium corresponding to the fast reactions of the pathway, and to derive a reduced-order nonlinear model of the pathway dynamics for the time scale of interest, in terms of suitable linear combinations of the species concentrations. Numerical simulations were performed to validate the utilization of the reduced model in the description of the metabolic network.
AB - A nonlinear model reduction method based on time scale analysis was applied to a detailed mechanistic model of the glucose catabolic pathway in S. cerevisiae. The method allows to identify quasi steady state constraints of complete conversion and reaction equilibrium corresponding to the fast reactions of the pathway, and to derive a reduced-order nonlinear model of the pathway dynamics for the time scale of interest, in terms of suitable linear combinations of the species concentrations. Numerical simulations were performed to validate the utilization of the reduced model in the description of the metabolic network.
UR - http://www.scopus.com/inward/record.url?scp=0036060844&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036060844&partnerID=8YFLogxK
U2 - 10.1109/acc.2002.1025224
DO - 10.1109/acc.2002.1025224
M3 - Conference article
AN - SCOPUS:0036060844
SN - 0743-1619
VL - 4
SP - 2867
EP - 2872
JO - Proceedings of the American Control Conference
JF - Proceedings of the American Control Conference
T2 - 2002 American Control Conference
Y2 - 8 May 2002 through 10 May 2002
ER -