Non-invasive transcranial surgery with dual-mode ultrasound arrays

Alyona Haritonova, Dalong Liu, Elias Wilken-Resman, Mahdi Bayat, Xiao Wang, Wei Chen, Afshin Divani, Emad Ebbini

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We present the first transcranial mapping of temperature with Dual-Mode Ultrasound Arrays (DMUAs), with subsequent validation of transskull ultrasound therapy guidance and monitoring in a small rodent model. Experiments were conducted in sacrificed rats, utilizing the custom designed DMUA platform manufactured in our laboratory. First, careful examination of DMUA imaging through the skull was conducted, where a fine 50μm wire was embedded within the brain tissue. Second, anatomical landmarks were visualized by co-registering two volumes, volume of synthetic aperture (SA) images acquired with DMUA and a 9.4T MRI volume acquired in live rats prior to the sacrifice. Third, subtherapeutic shot delivery through the skull was tested, where a set of five varying intensity shots were deposited below the skull surface. Shot delivery and temperature monitoring were performed with DMUA, and compared with the thermocouple data acquired close to the therapeutic focus. This study was an exploratory effort to validate ultrasound therapy delivery and monitoring in transcranial applications with DMUAs. In conclusion, DMUAs offer a unique advantage by providing real-time feedback by means of temperature monitoring with a high degree of spatial localization.

Original languageEnglish (US)
Title of host publicationProceedings from the 14th International Symposium on Therapeutic Ultrasound, ISTU 2014
EditorsJ. Brian Fowlkes, Vasant A. Salgaonkar
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735414891
DOIs
StatePublished - Mar 17 2017
Event14th International Symposium on Therapeutic Ultrasound, ISTU 2014 - Las Vegas, United States
Duration: Apr 2 2014Apr 5 2014

Publication series

NameAIP Conference Proceedings
Volume1821
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Other

Other14th International Symposium on Therapeutic Ultrasound, ISTU 2014
CountryUnited States
CityLas Vegas
Period4/2/144/5/14

Keywords

  • Brain
  • DMUA
  • HIFU
  • Imaging
  • Temperature
  • Thermocouple
  • Transcranial

Fingerprint Dive into the research topics of 'Non-invasive transcranial surgery with dual-mode ultrasound arrays'. Together they form a unique fingerprint.

  • Cite this

    Haritonova, A., Liu, D., Wilken-Resman, E., Bayat, M., Wang, X., Chen, W., Divani, A., & Ebbini, E. (2017). Non-invasive transcranial surgery with dual-mode ultrasound arrays. In J. B. Fowlkes, & V. A. Salgaonkar (Eds.), Proceedings from the 14th International Symposium on Therapeutic Ultrasound, ISTU 2014 [050004] (AIP Conference Proceedings; Vol. 1821). American Institute of Physics Inc.. https://doi.org/10.1063/1.4977623