Abstract
We present the first transcranial mapping of temperature with Dual-Mode Ultrasound Arrays (DMUAs), with subsequent validation of transskull ultrasound therapy guidance and monitoring in a small rodent model. Experiments were conducted in sacrificed rats, utilizing the custom designed DMUA platform manufactured in our laboratory. First, careful examination of DMUA imaging through the skull was conducted, where a fine 50μm wire was embedded within the brain tissue. Second, anatomical landmarks were visualized by co-registering two volumes, volume of synthetic aperture (SA) images acquired with DMUA and a 9.4T MRI volume acquired in live rats prior to the sacrifice. Third, subtherapeutic shot delivery through the skull was tested, where a set of five varying intensity shots were deposited below the skull surface. Shot delivery and temperature monitoring were performed with DMUA, and compared with the thermocouple data acquired close to the therapeutic focus. This study was an exploratory effort to validate ultrasound therapy delivery and monitoring in transcranial applications with DMUAs. In conclusion, DMUAs offer a unique advantage by providing real-time feedback by means of temperature monitoring with a high degree of spatial localization.
| Original language | English (US) |
|---|---|
| Title of host publication | Proceedings from the 14th International Symposium on Therapeutic Ultrasound, ISTU 2014 |
| Editors | J. Brian Fowlkes, Vasant A. Salgaonkar |
| Publisher | American Institute of Physics Inc. |
| ISBN (Electronic) | 9780735414891 |
| DOIs | |
| State | Published - Mar 17 2017 |
| Event | 14th International Symposium on Therapeutic Ultrasound, ISTU 2014 - Las Vegas, United States Duration: Apr 2 2014 → Apr 5 2014 |
Publication series
| Name | AIP Conference Proceedings |
|---|---|
| Volume | 1821 |
| ISSN (Print) | 0094-243X |
| ISSN (Electronic) | 1551-7616 |
Other
| Other | 14th International Symposium on Therapeutic Ultrasound, ISTU 2014 |
|---|---|
| Country | United States |
| City | Las Vegas |
| Period | 4/2/14 → 4/5/14 |
Fingerprint
Keywords
- Brain
- DMUA
- HIFU
- Imaging
- Temperature
- Thermocouple
- Transcranial
Cite this
Non-invasive transcranial surgery with dual-mode ultrasound arrays. / Haritonova, Alyona; Liu, Dalong; Wilken-Resman, Elias; Bayat, Mahdi; Wang, Xiao; Chen, Wei; Divani, Afshin A; Ebbini, Emad S.
Proceedings from the 14th International Symposium on Therapeutic Ultrasound, ISTU 2014. ed. / J. Brian Fowlkes; Vasant A. Salgaonkar. American Institute of Physics Inc., 2017. 050004 (AIP Conference Proceedings; Vol. 1821).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Non-invasive transcranial surgery with dual-mode ultrasound arrays
AU - Haritonova, Alyona
AU - Liu, Dalong
AU - Wilken-Resman, Elias
AU - Bayat, Mahdi
AU - Wang, Xiao
AU - Chen, Wei
AU - Divani, Afshin A
AU - Ebbini, Emad S
PY - 2017/3/17
Y1 - 2017/3/17
N2 - We present the first transcranial mapping of temperature with Dual-Mode Ultrasound Arrays (DMUAs), with subsequent validation of transskull ultrasound therapy guidance and monitoring in a small rodent model. Experiments were conducted in sacrificed rats, utilizing the custom designed DMUA platform manufactured in our laboratory. First, careful examination of DMUA imaging through the skull was conducted, where a fine 50μm wire was embedded within the brain tissue. Second, anatomical landmarks were visualized by co-registering two volumes, volume of synthetic aperture (SA) images acquired with DMUA and a 9.4T MRI volume acquired in live rats prior to the sacrifice. Third, subtherapeutic shot delivery through the skull was tested, where a set of five varying intensity shots were deposited below the skull surface. Shot delivery and temperature monitoring were performed with DMUA, and compared with the thermocouple data acquired close to the therapeutic focus. This study was an exploratory effort to validate ultrasound therapy delivery and monitoring in transcranial applications with DMUAs. In conclusion, DMUAs offer a unique advantage by providing real-time feedback by means of temperature monitoring with a high degree of spatial localization.
AB - We present the first transcranial mapping of temperature with Dual-Mode Ultrasound Arrays (DMUAs), with subsequent validation of transskull ultrasound therapy guidance and monitoring in a small rodent model. Experiments were conducted in sacrificed rats, utilizing the custom designed DMUA platform manufactured in our laboratory. First, careful examination of DMUA imaging through the skull was conducted, where a fine 50μm wire was embedded within the brain tissue. Second, anatomical landmarks were visualized by co-registering two volumes, volume of synthetic aperture (SA) images acquired with DMUA and a 9.4T MRI volume acquired in live rats prior to the sacrifice. Third, subtherapeutic shot delivery through the skull was tested, where a set of five varying intensity shots were deposited below the skull surface. Shot delivery and temperature monitoring were performed with DMUA, and compared with the thermocouple data acquired close to the therapeutic focus. This study was an exploratory effort to validate ultrasound therapy delivery and monitoring in transcranial applications with DMUAs. In conclusion, DMUAs offer a unique advantage by providing real-time feedback by means of temperature monitoring with a high degree of spatial localization.
KW - Brain
KW - DMUA
KW - HIFU
KW - Imaging
KW - Temperature
KW - Thermocouple
KW - Transcranial
UR - http://www.scopus.com/inward/record.url?scp=85028943116&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85028943116&partnerID=8YFLogxK
U2 - 10.1063/1.4977623
DO - 10.1063/1.4977623
M3 - Conference contribution
T3 - AIP Conference Proceedings
BT - Proceedings from the 14th International Symposium on Therapeutic Ultrasound, ISTU 2014
A2 - Fowlkes, J. Brian
A2 - Salgaonkar, Vasant A.
PB - American Institute of Physics Inc.
ER -