Non-invasive measurement of cerebral oxygen metabolism in the mouse brain by ultra-high field 17O MR spectroscopy

Weina Cui, Xiao Hong Zhu, Manda L. Vollmers, Emily T. Colonna, Gregor Adriany, Brandon Tramm, Janet M. Dubinsky, Gülin Öz

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

To assess cerebral energetics in transgenic mouse models of neurologic disease, a robust, efficient, and practical method for quantification of cerebral oxygen consumption is needed. 17O magnetic resonance spectroscopy (MRS) has been validated to measure cerebral metabolic rate of oxygen (CMRO2) in the rat brain; however, mice present unique challenges because of their small size. We show that CMRO2 measurements with 17O MRS in the mouse brain are highly reproducible using 16.4 Tesla and a newly designed oxygen delivery system. The method can be utilized to measure mitochondrial function in mice quickly and repeatedly, without oral intubation, and has numerous potential applications to study cerebral energetics.

Original languageEnglish (US)
Pages (from-to)1846-1849
Number of pages4
JournalJournal of Cerebral Blood Flow and Metabolism
Volume33
Issue number12
DOIs
StatePublished - Dec 2013

Keywords

  • Cerebral metabolic rate of oxygen
  • Magnetic resonance spectroscopic imaging
  • Mouse
  • Oxygen-17

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