Non-immune hydrops fetalis caused by herpes simplex virus type 2 in the setting of recurrent maternal infection

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Abstract

We report a case of non-immune hydrops fetalis (NIHF) caused by herpes simplex virus type 2 (HSV-2) in an infant whose mother had recurrent HSV-2 infection. In spite of prematurity, severe disseminated infection and hydrops, the infant survived and was neurologically intact. HSV-2-induced NIHF is extremely rare, particularly in the setting of recurrent maternal infection, and this case is, to our knowledge, the first report of a surviving infant. HSV-2 should be considered in the differential diagnosis of NIHF and early initiation of empiric acyclovir therapy is recommended in this setting, pending the results of virologic diagnostic tests.

Original languageEnglish (US)
Pages (from-to)817-820
Number of pages4
JournalJournal of Perinatology
Volume33
Issue number10
DOIs
StatePublished - Oct 1 2013

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Keywords

  • Acyclovir
  • Fetal hydrops
  • HSV-2 infection
  • Neonatal HSV infection
  • Placental infection
  • Torch infection

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