Non-immune hydrops fetalis caused by herpes simplex virus type 2 in the setting of recurrent maternal infection

K. M. Pfister; M. R. Schleiss; R. C. Reed; T. N. George

doi:10.1038/jp.2013.68

Non-immune hydrops fetalis caused by herpes simplex virus type 2 in the setting of recurrent maternal infection

K. M. Pfister, M. R. Schleiss, R. C. Reed, T. N. George

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

We report a case of non-immune hydrops fetalis (NIHF) caused by herpes simplex virus type 2 (HSV-2) in an infant whose mother had recurrent HSV-2 infection. In spite of prematurity, severe disseminated infection and hydrops, the infant survived and was neurologically intact. HSV-2-induced NIHF is extremely rare, particularly in the setting of recurrent maternal infection, and this case is, to our knowledge, the first report of a surviving infant. HSV-2 should be considered in the differential diagnosis of NIHF and early initiation of empiric acyclovir therapy is recommended in this setting, pending the results of virologic diagnostic tests.

Original language	English (US)
Pages (from-to)	817-820
Number of pages	4
Journal	Journal of Perinatology
Volume	33
Issue number	10
DOIs	https://doi.org/10.1038/jp.2013.68
State	Published - Oct 2013

Keywords

Acyclovir
Fetal hydrops
HSV-2 infection
Neonatal HSV infection
Placental infection
Torch infection

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title = "Non-immune hydrops fetalis caused by herpes simplex virus type 2 in the setting of recurrent maternal infection",

abstract = "We report a case of non-immune hydrops fetalis (NIHF) caused by herpes simplex virus type 2 (HSV-2) in an infant whose mother had recurrent HSV-2 infection. In spite of prematurity, severe disseminated infection and hydrops, the infant survived and was neurologically intact. HSV-2-induced NIHF is extremely rare, particularly in the setting of recurrent maternal infection, and this case is, to our knowledge, the first report of a surviving infant. HSV-2 should be considered in the differential diagnosis of NIHF and early initiation of empiric acyclovir therapy is recommended in this setting, pending the results of virologic diagnostic tests.",

keywords = "Acyclovir, Fetal hydrops, HSV-2 infection, Neonatal HSV infection, Placental infection, Torch infection",

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AU - Pfister, K. M.

AU - Schleiss, M. R.

AU - Reed, R. C.

AU - George, T. N.

PY - 2013/10

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AB - We report a case of non-immune hydrops fetalis (NIHF) caused by herpes simplex virus type 2 (HSV-2) in an infant whose mother had recurrent HSV-2 infection. In spite of prematurity, severe disseminated infection and hydrops, the infant survived and was neurologically intact. HSV-2-induced NIHF is extremely rare, particularly in the setting of recurrent maternal infection, and this case is, to our knowledge, the first report of a surviving infant. HSV-2 should be considered in the differential diagnosis of NIHF and early initiation of empiric acyclovir therapy is recommended in this setting, pending the results of virologic diagnostic tests.

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KW - Neonatal HSV infection

KW - Placental infection

KW - Torch infection

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Non-immune hydrops fetalis caused by herpes simplex virus type 2 in the setting of recurrent maternal infection

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