Non-HLA barriers to unrelated donor stem cell transplantation

C. Kollman, T. Weis, G. E. Switzer, M. Halet, D. Kitajima, J. Hegland, D. L. Confer

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


A prospective survey involving 544 searches of the US National Marrow Donor Program (NMDP) Registry was conducted to identify reasons why many patients who have apparent HLA-matched donors do not proceed to transplant. Coordinators at NMDP transplant centers, patients and referring physicians were surveyed shortly after the initial search, and follow-up surveys were sent to the coordinators as the search was ongoing. The death of the patient, worsening of the patient's medical condition and length of the search process were the most commonly cited barriers to transplantation. Other times a decision was made not to transplant through the NMDP due to the use of a donor from another source, a preference for chemotherapy or immunotherapy, hesitancy on the part of the transplant physician or patient, or because the patient did not require a transplant. Responses differed between U.S. and international cases. An unrelated donor outside the NMDP was the most common reason cited by international coordinators (46%), whereas the death of the patient was the most common reason among US coordinators (13%). The death of the patient was the second most common reason cited by international coordinators at 9%. Financial problems were listed by 41% of US coordinators as a potential barrier at the time of initial search, but only 5% indicated this as an actual barrier on a follow-up survey. Finances were cited as the most important reason 3% of the time overall, and 6% for African Americans and Asian/Pacific Islanders.

Original languageEnglish (US)
Pages (from-to)581-587
Number of pages7
JournalBone marrow transplantation
Issue number6
StatePublished - 2001

Bibliographical note

Funding Information:
We would like to extend our appreciation to the NMDP transplant center coordinators and referring physicians who took the time and effort to complete the surveys for this study. We especially want to thank the patients and their families for their willingness to share a part of their experience during a time of deep personal crisis in the hope of helping others. We are also grateful to Nancy Morgan for her assistance in the preparation of this manuscript. This work was supported by the National Marrow Donor Program in part through funding from the Health Resources and Services Administration (Contract No. 240–97–0036) and the Office of Naval Research (Cooperative Agreement Nos N00014–96–2– 0016 and N00014–99–2–0006). The views expressed in this article do not reflect the official policy or position of the Department of the Navy, the Department of Defense, or the US government.


  • Barriers
  • Registry
  • Search
  • Survey
  • Unrelated


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