Abstract
The goal of this project was to determine the effect of the thickness of the coating film on the dissolution behavior of tablets. Commercially available film-coated tablets containing aspirin, acetaminophen and caffeine, were used as the model system. First, a non-destructive X-ray microdiffractometric technique was developed to quantify the thickness of the film-coating in intact tablets. The same tablets were then subjected to dissolution tests. There was an inverse correlation between the cumulative amount of drug in solution at 5 min and the thickness of the coating film. As the coating thickness increased, the initiation of tablet dissolution was delayed, resulting in a decrease in the cumulative amount of drug in solution. Finally, the technique was applied to formulations marketed by different companies. The X-ray microdiffractometric technique has the potential to predict the dissolution behavior of tablets.
Original language | English (US) |
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Pages (from-to) | 952-957 |
Number of pages | 6 |
Journal | Journal of Pharmaceutical and Biomedical Analysis |
Volume | 51 |
Issue number | 4 |
DOIs | |
State | Published - Mar 11 2010 |
Bibliographical note
Copyright:Copyright 2010 Elsevier B.V., All rights reserved.
Keywords
- Coating film thickness
- Dissolution
- Film-coated tablet
- Microdiffractometry
- X-ray