Non-catalytic roles of the topoisomerase IIα C-terminal domain

Duncan J. Clarke, Yoshiaki Azuma

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

DNA Topoisomerase IIα (Topo IIα) is a ubiquitous enzyme in eukaryotes that performs the strand passage reaction where a double helix of DNA is passed through a second double helix. This unique reaction is critical for numerous cellular processes. However, the enzyme also possesses a C-terminal domain (CTD) that is largely dispensable for the strand passage reaction but is nevertheless important for the fidelity of cell division. Recent studies have expanded our understanding of the roles of the Topo IIα CTD, in particular in mitotic mechanisms where the CTD is modified by Small Ubiquitin-like Modifier (SUMO), which in turn provides binding sites for key regulators of mitosis.

Original languageEnglish (US)
Article number2438
JournalInternational journal of molecular sciences
Volume18
Issue number11
DOIs
StatePublished - Nov 17 2017

Bibliographical note

Funding Information:
Research from our laboratories that is described in this review article was supported by NIH/NIGMS, GM112793.

Publisher Copyright:
© 2017 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • Aurora B
  • C-terminal domain
  • Claspin
  • Haspin
  • Metaphase checkpoint
  • Mitosis
  • SUMO
  • Topoisomerase II

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