DNA Topoisomerase IIα (Topo IIα) is a ubiquitous enzyme in eukaryotes that performs the strand passage reaction where a double helix of DNA is passed through a second double helix. This unique reaction is critical for numerous cellular processes. However, the enzyme also possesses a C-terminal domain (CTD) that is largely dispensable for the strand passage reaction but is nevertheless important for the fidelity of cell division. Recent studies have expanded our understanding of the roles of the Topo IIα CTD, in particular in mitotic mechanisms where the CTD is modified by Small Ubiquitin-like Modifier (SUMO), which in turn provides binding sites for key regulators of mitosis.
Bibliographical noteFunding Information:
Research from our laboratories that is described in this review article was supported by NIH/NIGMS, GM112793.
© 2017 by the authors. Licensee MDPI, Basel, Switzerland.
- Aurora B
- C-terminal domain
- Metaphase checkpoint
- Topoisomerase II