Non-apoptotic fas (CD95) signaling on T cells regulates the resolution of Th2-mediated inflammation

Jesse W. Williams, Caroline M. Ferreira, Kelly M. Blaine, Crystal Rayon, Francisco Velázquez, Jiankun Tong, Marcus E. Peter, Anne I. Sperling

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Fas (CD95/APO-1) and its ligand (FasL/CD95L) promote the resolution of type 2 lung inflammation and eosinophilia. We previously found that Fas-deficiency on T cells, but not eosinophils, delayed resolution of inflammation. However, Fas can signal both cell death and have a positive signaling function that can actually activate cells. In this study, we investigated whether Fas-induced death or Fas-activated signaling pathways promote resolution of allergic lung inflammation. By increasing T cell survival through two Fas-independent pathways, using Bim-deficient T cells or Bcl-xL overexpressing T cells, no differences in resolution of Th2-mediated inflammation was observed. Furthermore, Th2 cells were inherently resistant to Fas-mediated apoptosis and preferentially signaled through non-apoptotic pathways following FasL treatment. Utilizing Fas-mutant mice deficient in apoptotic but sufficient for non-apoptotic Fas signaling pathways, we demonstrate that non-apoptotic Fas signaling in T cells drives resolution of Th2-mediated airway inflammation. Our findings reveal a previously unknown role for non-apoptotic Fas signaling on Th2 cells in the induction of resolution of type 2 inflammation.

Original languageEnglish (US)
Article number02521
JournalFrontiers in immunology
Volume9
Issue numberNOV
DOIs
StatePublished - Nov 1 2018

Bibliographical note

Publisher Copyright:
Copyright © 2018 Williams, Ferreira, Blaine, Rayon, Velázquez, Tong, Peter and Sperling. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.

Keywords

  • Allergy
  • Apoptosis
  • Asthma
  • Eosinophilia
  • Fas-FasL
  • Th2 cells

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

Fingerprint Dive into the research topics of 'Non-apoptotic fas (CD95) signaling on T cells regulates the resolution of Th2-mediated inflammation'. Together they form a unique fingerprint.

Cite this