NOise Reduction with DIstribution Corrected (NORDIC) PCA improves signal-to-noise in rodent resting-state and optogenetic functional MRI

Russell W. Chan, Royce P. Lee, Sarah Y. Wu, Emily L. Tse, Yixi Xue, Steen Moeller, Kevin C. Chan

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

NOise Reduction with DIstribution Corrected (NORDIC) principal component analysis (PCA) has been shown to selectively suppress thermal noise and improve temporal signal-to-noise ratio (tSNR) in human functional magnetic resonance imaging (fMRI). However, the feasibility to improve rodent fMRI using NORDIC PCA has not been explored. In this study, we developed a rodent fMRI preprocessing pipeline by incorporating NORDIC and evaluated its performance in a range of rodent fMRI applications from resting-state fMRI to task-evoked fMRI using optogenetics. In resting-state fMRI, we demonstrated a significant increase in tSNR by more than 3 times after NORDIC correction with reduced variance and improved task-free relative cerebrovascular reactivity (rCVR) across cortical depth. In optogenetic fMRI, apart from tSNR increase, more activated voxels and a significant decrease in the variance of activated brain signals were observed after NORDIC correction without apparent change in brain morphology. Taken together, our results signified the values of NORDIC correction for better detection of brain activities in rodent fMRI. Clinical Relevance: NORDIC PCA increases temporal signalto- noise ratio in rodent resting-state and task-evoked functional MRI, which can play an important role in improving the image quality for translational medicine and preclinical research, and for guiding future clinical neuroimaging.

Original languageEnglish (US)
Title of host publication44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2022
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1847-1850
Number of pages4
Volume2022
ISBN (Electronic)9781728127828
DOIs
StatePublished - 2022
Event44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2022 - Glasgow, United Kingdom
Duration: Jul 11 2022Jul 15 2022

Publication series

Name2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)

Conference

Conference44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2022
Country/TerritoryUnited Kingdom
CityGlasgow
Period7/11/227/15/22

Bibliographical note

Funding Information:
This work was supported in part by the National Institutes of Health R01-EY028125, UF1-NS107680, P41-EB027061 and P41-EB027061-03S1; BrightFocus Foundation G2013077, G2016030, and G2019103; and an unrestricted grant from Research to Prevent Blindness to NYU Langone Health Department of Ophthalmology.

Publisher Copyright:
© 2022 IEEE.

Keywords

  • Animals
  • Brain Mapping/methods
  • Humans
  • Magnetic Resonance Imaging/methods
  • Optogenetics
  • Principal Component Analysis
  • Rodentia

Center for Magnetic Resonance Research (CMRR) tags

  • IRP

PubMed: MeSH publication types

  • Research Support, Non-U.S. Gov't
  • Journal Article
  • Research Support, N.I.H., Extramural

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