NOise Reduction with DIstribution Corrected (NORDIC) principal component analysis (PCA) has been shown to selectively suppress thermal noise and improve temporal signal-to-noise ratio (tSNR) in human functional magnetic resonance imaging (fMRI). However, the feasibility to improve rodent fMRI using NORDIC PCA has not been explored. In this study, we developed a rodent fMRI preprocessing pipeline by incorporating NORDIC and evaluated its performance in a range of rodent fMRI applications from resting-state fMRI to task-evoked fMRI using optogenetics. In resting-state fMRI, we demonstrated a significant increase in tSNR by more than 3 times after NORDIC correction with reduced variance and improved task-free relative cerebrovascular reactivity (rCVR) across cortical depth. In optogenetic fMRI, apart from tSNR increase, more activated voxels and a significant decrease in the variance of activated brain signals were observed after NORDIC correction without apparent change in brain morphology. Taken together, our results signified the values of NORDIC correction for better detection of brain activities in rodent fMRI. Clinical Relevance: NORDIC PCA increases temporal signalto- noise ratio in rodent resting-state and task-evoked functional MRI, which can play an important role in improving the image quality for translational medicine and preclinical research, and for guiding future clinical neuroimaging.
|Original language||English (US)|
|Title of host publication||44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2022|
|Publisher||Institute of Electrical and Electronics Engineers Inc.|
|Number of pages||4|
|State||Published - 2022|
|Event||44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2022 - Glasgow, United Kingdom|
Duration: Jul 11 2022 → Jul 15 2022
|Name||2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)|
|Conference||44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2022|
|Period||7/11/22 → 7/15/22|
Bibliographical noteFunding Information:
This work was supported in part by the National Institutes of Health R01-EY028125, UF1-NS107680, P41-EB027061 and P41-EB027061-03S1; BrightFocus Foundation G2013077, G2016030, and G2019103; and an unrestricted grant from Research to Prevent Blindness to NYU Langone Health Department of Ophthalmology.
© 2022 IEEE.
- Brain Mapping/methods
- Magnetic Resonance Imaging/methods
- Principal Component Analysis
PubMed: MeSH publication types
- Research Support, Non-U.S. Gov't
- Journal Article
- Research Support, N.I.H., Extramural