Nodal gliomatosis and α-fetoprotein production: Two unusual facets of grade I ovarian teratoma

T. Perrone, Marie E Steiner, L. P. Dehner

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

We describe the case of a 10-month-old infant who had a grade I solid teratoma of the ovary. It is remarkable that the tumor was accompanied by nodal gliomatosis and elevated serum α-fetoprotein (AFP) level. To our knowledge, this is the first description of nodal gliomatosis in the absence of gliomatosis peritonei, and the fifth report of elevated serum AFP with a pure teratoma. Like gliomatosis peritonei, nodal gliomatosis appears to be a benign condition, requiring no adjuvant therapy. The nature of the nodal implants was confirmed by positive immunoreactivity for glial fibrillary acidic protein. By a similar method, AFP was found in the primary tumor in cells lining yold-sac-like vesicles and intestinal-type glands.

Original languageEnglish (US)
Pages (from-to)975-977
Number of pages3
JournalArchives of Pathology and Laboratory Medicine
Volume110
Issue number10
StatePublished - Dec 1 1986

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