Abstract
Ambulatory blood pressure (BP) monitoring is superior to clinic BP monitoring in predicting long-term consequences of hypertension. This has raised interest in diurnal variation in BP and elevation in nighttime BP as a prognostic and therapeutic target. Several studies have identified prevalence of nocturnal hypertension in patients with accelerated progression of chronic kidney disease and target organ damage. Some studies suggest that nocturnal BP can be lowered by changing administration of antihypertensive medication to bed time; whether that results in retarding kidney disease progression is not very clear. Further research is needed to determine if certain classes of medications or interventions are superior in controlling nocturnal hypertension, and protocols need to be developed to screen patients for monitoring nocturnal BP. Further studies are needed to evaluate long-term renal outcomes of evening dosing in patients with nocturnal hypertension and chronic kidney disease.
Original language | English (US) |
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Pages (from-to) | 449-454 |
Number of pages | 6 |
Journal | Current Hypertension Reports |
Volume | 14 |
Issue number | 5 |
DOIs | |
State | Published - Oct 1 2012 |
Externally published | Yes |
Keywords
- Ambulatory blood pressure
- Antihypertensive drug therapy
- BP
- Blood pressure
- CKD
- Chronic kidney disease
- Chronotherapy
- Diurnal patterns
- Elevated nighttime blood pressure
- Extreme dipping
- Hypertension
- Nighttime dipping
- Nocturnal hypertension
- Nondipping
- Reverse dipping