Nocturnal medications dosing: Does it really make a difference in blood pressure control among patients with chronic kidney disease

Salman Rasheed Mallick, Mahboob Rahman

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Ambulatory blood pressure (BP) monitoring is superior to clinic BP monitoring in predicting long-term consequences of hypertension. This has raised interest in diurnal variation in BP and elevation in nighttime BP as a prognostic and therapeutic target. Several studies have identified prevalence of nocturnal hypertension in patients with accelerated progression of chronic kidney disease and target organ damage. Some studies suggest that nocturnal BP can be lowered by changing administration of antihypertensive medication to bed time; whether that results in retarding kidney disease progression is not very clear. Further research is needed to determine if certain classes of medications or interventions are superior in controlling nocturnal hypertension, and protocols need to be developed to screen patients for monitoring nocturnal BP. Further studies are needed to evaluate long-term renal outcomes of evening dosing in patients with nocturnal hypertension and chronic kidney disease.

Original languageEnglish (US)
Pages (from-to)449-454
Number of pages6
JournalCurrent Hypertension Reports
Volume14
Issue number5
DOIs
StatePublished - Oct 1 2012
Externally publishedYes

Keywords

  • Ambulatory blood pressure
  • Antihypertensive drug therapy
  • BP
  • Blood pressure
  • CKD
  • Chronic kidney disease
  • Chronotherapy
  • Diurnal patterns
  • Elevated nighttime blood pressure
  • Extreme dipping
  • Hypertension
  • Nighttime dipping
  • Nocturnal hypertension
  • Nondipping
  • Reverse dipping

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